Qi Zhang

TL;DR: Clinicians and public health officials should be aware of underlying chronic infections such as tuberculosis in COVID-19 patients in Wuhan, China.

TL;DR: The accumulated data suggest that IL-1β probably induces vascular leakage and tissue injury in interferon-alpha/beta receptor 1 deficient C57BL/6 mice (IFNAR–/– C57 BL/6), whereas IL-2 receptor antagonist (IL-1RA) alleviates these effects of IL- 1β.

TL;DR: The discovery and characterization of the TBN biosynthetic pathway from Streptomyces tubercidicus NBRC 13090 via reconstitution of its production in a heterologous host is reported and lays a foundation for the rational generation of TBN analogs through synthetic biology strategy.

TL;DR: It is reported that BDV inhibits the activation of inducible nitric oxide synthase (iNOS) in murine astrocytes induced by bacterial LPS and PMA and functional analysis indicated that sequences from amino acids 134 to 174 of the P protein are necessary for the regulation of iNOS.

TL;DR: EV71 stimulates SIRT1 production and activity, which in turn represses EV71 genome replication by inhibiting viral polymerase, and attenuates EV71 RNA transcription and translation by interfering with viral RNA.