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Yan Liu
Researcher at Wuhan University
Publications - 9
Citations - 2873
Yan Liu is an academic researcher from Wuhan University. The author has contributed to research in topics: Viral entry & Virus. The author has an hindex of 7, co-authored 9 publications receiving 2013 citations. Previous affiliations of Yan Liu include Peking Union Medical College.
Papers
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Journal ArticleDOI
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.
Xiuyuan Ou,Yan Liu,Xiaobo Lei,Pei Li,Dan Mi,Lili Ren,Li Guo,Ruixuan Guo,Ting Chen,Jiaxin Hu,Zichun Xiang,Zhixia Mu,Xing Chen,Jieyong Chen,Keping Hu,Qi Jin,Jianwei Wang,Zhaohui Qian +17 more
TL;DR: It is shown that the SARS-CoV-2 spike protein is less stable than that of SARS -CoV, and limited cross-neutralization activities between SARS and COVID-19 patients’ sera showlimited cross- neutralization activities, suggesting that recovery from one infection might not protect against the other.
Journal ArticleDOI
Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection.
Wei Li,Yan Liu,Muhammad Mukhtar,Rui Gong,Ying Pan,Sahibzada Tasleem Rasool,Yecheng Gao,Lei Kang,Qian Hao,Guiqing Peng,Yanni Chen,Xin Chen,Jianguo Wu,Ying Zhu +13 more
TL;DR: IL-32 is induced by influenza A virus infection via COX-2 in the inflammatory cascade and is a potential target for anti-inflammatory medicine screening, suggesting there was a feedback mechanism between IL-32 and COX2.
Journal ArticleDOI
Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection
Wei Li,Fang Yang,Yan Liu,Rui Gong,Li Liu,Yong Feng,Pan Hu,Wei Sun,Qian Hao,Lei Kang,Jianguo Wu,Ying Zhu +11 more
TL;DR: It is suggested that influenza A virus infection activates IL‐32 and iNOS expression by a heretofore unrecognized complex mechanism, in which the two pro‐inflammatory factors regulate each other, involving positive and negative feedback regulatory loops.
Journal ArticleDOI
SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation.
Luyao Shao,Yan Liu,Wenbiao Wang,Aixin Li,Pin Wan,Weiyong Liu,Muhammad Adnan Shereen,Fang Liu,Wen Zhang,Quiping Tan,Kailang Wu,Yingle Liu,Yingle Liu,Jianguo Wu,Jianguo Wu +14 more
TL;DR: It is revealed that SUMO1‐catalyzed SUMoylation and SENP3‐mediated deSUMOylation of NLRP3 orchestrate the inflammasome activation.
Journal ArticleDOI
Retinoic acid activates human inducible nitric oxide synthase gene through binding of RARα/RXRα heterodimer to a novel retinoic acid response element in the promoter
TL;DR: The results suggested the identification of a novel RARE in theHiNOS promoter and the roles of the nuclear receptors (RARalpha/RXRalpha) in the induction of hiNOS by RA.