Q
Qing Chang
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 20
Citations - 1587
Qing Chang is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Breast cancer & Carcinogenesis. The author has an hindex of 10, co-authored 18 publications receiving 1081 citations.
Papers
More filters
Journal ArticleDOI
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer
Pasquale Sansone,Claudia Savini,Ivana Kurelac,Qing Chang,Laura Benedetta Amato,Antonio Strillacci,Antonio Strillacci,Anna Stepanova,Luisa Iommarini,Chiara Mastroleo,Laura Daly,Alexander Galkin,Alexander Galkin,Basant Kumar Thakur,Nadine Soplop,Kunihiro Uryu,Ayuko Hoshino,Larry Norton,Massimiliano Bonafè,Monica Cricca,Giuseppe Gasparre,David Lyden,David Lyden,Jacqueline Bromberg,Jacqueline Bromberg +24 more
TL;DR: It is demonstrated that the horizontal transfer of mtDNA from EVs acts as an oncogenic signal promoting an exit from dormancy of therapy-induced cancer stem-like cells and leading to endocrine therapy resistance in OXPHOS-dependent breast cancer.
Journal ArticleDOI
The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis
Qing Chang,Eirini Bournazou,Pasquale Sansone,Marjan Berishaj,Sizhi Paul Gao,Laura Daly,Jared Wels,Till Martin Theilen,Selena Granitto,Xinmin Zhang,Jesse W. Cotari,Mary L. Alpaugh,Elisa de Stanchina,Katia Manova,Ming O. Li,Massimiliano Bonafè,Claudio Ceccarelli,Mario Taffurelli,Donatella Santini,Grégoire Altan-Bonnet,Rosandra N. Kaplan,Larry Norton,Norihiro Nishimoto,Dennis Huszar,David Lyden,David Lyden,Jacqueline Bromberg +26 more
TL;DR: This study provides the first evidence for IL-6 expression at the leading edge of invasive human breast tumors and demonstrates mechanistically that IL- 6/JAK/Stat3 signaling plays a critical and pharmacologically targetable role in orchestrating the composition of the tumor microenvironment that promotes growth, invasion, and metastasis.
Journal ArticleDOI
Self-renewal of CD133 hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer
Pasquale Sansone,Claudio Ceccarelli,Marjan Berishaj,Qing Chang,Vinagolu K. Rajasekhar,Fabiana Perna,Robert L. Bowman,Michele Vidone,Laura Daly,Jennifer Nnoli,Donatella Santini,Mario Taffurelli,Natalie N. C. Shih,Michael Feldman,Jun J. Mao,Christopher Colameco,Jinbo Chen,Angela DeMichele,Nicola Fabbri,John H. Healey,Monica Cricca,Giuseppe Gasparre,David Lyden,David Lyden,Massimiliano Bonafè,Jacqueline Bromberg,Jacqueline Bromberg +26 more
TL;DR: HT induces an OXPHOS metabolic editing of luminal breast cancers, paradoxically establishing HT-driven self-renewal of dormant CD133hi/ERlo cells mediating metastatic progression, which is sensitive to dual targeted therapy.
Journal ArticleDOI
RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling
Zhan Yao,Yijun Gao,Wenjing Su,Rona Yaeger,Rona Yaeger,Jessica J. Tao,Na Na,Ying Zhang,Chao Zhang,Andrey Rymar,Anthony Tao,Neilawattie M. Timaul,Rory Mcgriskin,Nathaniel A. Outmezguine,Hui Yong Zhao,Qing Chang,Besnik Qeriqi,Mariano Barbacid,Elisa de Stanchina,David M. Hyman,David M. Hyman,Gideon Bollag,Neal Rosen +22 more
TL;DR: As a BRAF-specific dimer breaker, PLX8394 selectively inhibits ERK signaling in tumors driven by dimeric BRAF mutants, including BRAF fusions and splice variants as well as BRAF V600 monomers, but spares RAF function in normal cells in which CRAF homodimers can drive signaling.
Journal ArticleDOI
Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles.
Pasquale Sansone,Marjan Berishaj,Vinagolu K. Rajasekhar,Claudio Ceccarelli,Qing Chang,Antonio Strillacci,Antonio Strillacci,Claudia Savini,Claudia Savini,Lauren Q. Shapiro,Robert L. Bowman,Chiara Mastroleo,Sabrina De Carolis,Laura Daly,Alberto Benito-Martin,Fabiana Perna,Nicola Fabbri,John H. Healey,Enzo Spisni,Monica Cricca,David Lyden,David Lyden,Massimiliano Bonafè,Massimiliano Bonafè,Jacqueline Bromberg,Jacqueline Bromberg +25 more
TL;DR: The results illuminate how microvesicle-mediated horizontal transfer of genetic material from host stromal cells to cancer cells triggers the evolution of therapy-resistant metastases, with potentially broad implications for their control.