Q
Qing Lu
Researcher at University of Maryland, Baltimore
Publications - 13
Citations - 798
Qing Lu is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Aromatase & Estrogen. The author has an hindex of 12, co-authored 12 publications receiving 792 citations.
Papers
More filters
Journal ArticleDOI
Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers.
Qing Lu,Junji Nakmura,Alexei Y. Savinov,Wei Yue,Judith Weisz,David J. Dabbs,Gabriella Wolz,Angela Brodie +7 more
TL;DR: The results indicate that aromatase is expressed mainly in tumor epithelial cells and that sufficient amounts of estrogen are synthesized by the tumor to produce a proliferative response.
Journal ArticleDOI
Estrogen regulates vascular endothelial growth/permeability factor expression in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors
TL;DR: It appears that E2 causes a rapid induction of VEG/PF expression in mammary tumors that is similar to that observed in the normal uterus, suggesting that one mechanism by which estrogen acts as a mammary tumor promotor is by stimulating V EG/PF, leading to increased tumor angiogenesis and/or permeability of the microvessels to allow tumor cell migration.
Journal ArticleDOI
Aromatase in the normal breast and breast cancer
TL;DR: The results suggest that some tumors synthesize sufficient estrogen to stimulate their proliferation, and it may thus be important to inhibit tumor aromatase as well as to reduce circulating levels of estrogen for effective breast cancer treatment.
Journal ArticleDOI
The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer.
TL;DR: The results show that treatment with the combinations of aromatase inhibitors with either tamoxifen or faslodex are not more effective in blocking estrogen stimulation of tumor growth than the aromat enzyme inhibitors alone.
Journal ArticleDOI
The effects of aromatase inhibitors and antiestrogens in the nude mouse model.
TL;DR: These aromatase inhibitors may not only benefit patients who have relapsed from tamoxifen, but may be more effective in patients as first line agents for suppressing the effects of estrogen.