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Qinghua Gao
Researcher at China Medical University (PRC)
Publications - 22
Citations - 190
Qinghua Gao is an academic researcher from China Medical University (PRC). The author has contributed to research in topics: Calmodulin & Cav1.2. The author has an hindex of 7, co-authored 19 publications receiving 147 citations. Previous affiliations of Qinghua Gao include Kagoshima University & Cardiovascular Institute of the South.
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Journal ArticleDOI
The alterations of Ca2+/Calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia
Dongyu Min,Feng Guo,Shu Zhu,Xiaoxue Xu,Xiao-Yuan Mao,Yonggang Cao,Xintong Lv,Qinghua Gao,Lei Wang,Tianbao Chen,Christopher Shaw,Liying Hao,Jiqun Cai +12 more
TL;DR: The results suggest that the alterations in CaV1.2, calmodulin, p-CaMKII,p-CREB and BDNF can be reflective of an involvement in the impairment in memory and cognition in AD and VD models.
Journal ArticleDOI
Nonylphenol affects myocardial contractility and L-type Ca2+ channel currents in a non-monotonic manner via G protein-coupled receptor 30
Qinghua Gao,Shuyuan Liu,Feng Guo,Shuice Liu,Xiangchen Yu,Huiyuan Hu,Xuefei Sun,Liying Hao,Tong Zhu +8 more
TL;DR: These non-monotonic changes in contractility correlated with the effects of NP on ICa-L, indicating that ion channels, as rapidly responding membrane proteins, play a very important role in mediating the rapid-response effects of XEs.
Journal ArticleDOI
PKA phosphorylation of Cav1.2 channel modulates the interaction of calmodulin with the C terminal tail of the channel.
TL;DR: The hypothesis that PKA phosphorylation may enhance channel activity and attenuate the Ca2+-dependent inactivation, at least partially, by modulating calmodulin- CT1 interaction both directly and indirectly via CT3-CT1 interaction is supported.
Journal ArticleDOI
The Ca2+‐dependent interaction of calpastatin domain L with the C‐terminal tail of the Cav1.2 channel
Wei Sun,Rui Feng,Rui Feng,Huiyuan Hu,Huiyuan Hu,Feng Guo,Feng Guo,Qinghua Gao,Qinghua Gao,Dongxue Shao,Dandan Yin,Hongmei Wang,Xuefei Sun,Xuefei Sun,Meimi Zhao,Meimi Zhao,Etsuko Minobe,Yingxian Sun,Guangyu Jiao,Masaki Kameyama,Liying Hao,Liying Hao +21 more
TL;DR: The results suggest that CSL may bind with both the IQ and PreIQ motifs of the Cav1.2 channel in different Ca2+‐dependent manners.
Journal ArticleDOI
The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart
Dongxue Shao,Meimi Zhao,Jianjun Xu,Rui Feng,Feng Guo,Huiyuan Hu,Xuefei Sun,Qinghua Gao,Guilin He,Wei Sun,Hongmei Wang,Lifeng Yu,Suyuan Liu,Yaonan Zhu,Etsuko Minobe,Tong Zhu,Masaki Kameyama,Liying Hao +17 more
TL;DR: Using the patch‐clamp technique, it is confirmed that the N‐ or C‐lobes can rescue the basal activity of Cav1.2 from run‐down, demonstrating the functional relevance of the individual lobes.