Q
Quteba Ebrahem
Researcher at Cleveland Clinic
Publications - 29
Citations - 1654
Quteba Ebrahem is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Angiogenesis & Neovascularization. The author has an hindex of 15, co-authored 29 publications receiving 1508 citations. Previous affiliations of Quteba Ebrahem include Case Western Reserve University & University of East Anglia.
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Journal ArticleDOI
A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2.
Jian Hua Qi,Quteba Ebrahem,Nina Z. Moore,Gillian Murphy,Lena Claesson-Welsh,Mark Bond,Andrew Baker,Bela Anand-Apte +7 more
TL;DR: The ability of TIMP3 to inhibit vascular endothelial factor (VEGF)–mediated angiogenesis is demonstrated and the potential mechanism by which this occurs is identified, indicating a new function for this molecule.
Journal ArticleDOI
Increased CDA Expression/Activity in Males Contributes to Decreased Cytidine Analog Half-Life and Likely Contributes to Worse Outcomes with 5-Azacytidine or Decitabine Therapy
Reda Z. Mahfouz,Ania Jankowska,Quteba Ebrahem,Xiaorong Gu,Valeria Visconte,Ali Tabarroki,Pramod S. Terse,Joseph M. Covey,Kenneth K. Chan,Yonghua Ling,Kory J. Engelke,Mikkael A. Sekeres,Ramon V. Tiu,Jaroslaw P. Maciejewski,Tomas Radivoyevitch,Yogen Saunthararajah +15 more
TL;DR: Increased CDA expression/activity in males contributes to decreased cytidine analog half-life and likely contributes to worse outcomes with 5-azacytidine or decitabine therapy.
Journal ArticleDOI
Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration
Quteba Ebrahem,Kutralanathan Renganathan,Kutralanathan Renganathan,Jonathan E. Sears,Amit Vasanji,Xiaorong Gu,Liang Lu,Robert G. Salomon,John W. Crabb,Bela Anand-Apte +9 more
TL;DR: Results suggest that CEP-induced angiogenesis utilizes VEGF-independent pathways and that anti-CEP therapeutic modalities might be of value in limiting CNV in AMD.
Journal ArticleDOI
Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy
TL;DR: Results imply that simulating hypoxia chemically by stabilizing HIF activity during the causative ischemia phase (hyperoxia) of retinopathy of prematurity may be of therapeutic value in preventing progression to the proliferative stage of the disease.
Journal ArticleDOI
Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates
Xiaorong Gu,Quteba Ebrahem,Reda Z. Mahfouz,Metis Hasipek,Francis Enane,Tomas Radivoyevitch,Nicolas Rapin,Bartlomiej P Przychodzen,Zhenbo Hu,Ramesh Balusu,Claudiu V. Cotta,David N. Wald,Christian Argueta,Yosef Landesman,Maria Paola Martelli,Brunangelo Falini,Hetty E. Carraway,Bo T. Porse,Jaroslaw P. Maciejewski,Babal K. Jha,Yogen Saunthararajah +20 more
TL;DR: In this paper, the authors analyzed the endogenous NPM1 protein interactome by mass spectrometry and discovered abundant amounts of the master transcription factor driver of monocyte lineage differentiation PU.1 (also known as SPI1).