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Bo T. Porse
Researcher at University of Copenhagen
Publications - 124
Citations - 9594
Bo T. Porse is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Haematopoiesis & Cellular differentiation. The author has an hindex of 48, co-authored 105 publications receiving 8225 citations. Previous affiliations of Bo T. Porse include University of Düsseldorf & Finsen Laboratory.
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Journal ArticleDOI
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
Adrian P. Bracken,Daniela Kleine-Kohlbrecher,Nikolaj Dietrich,Diego Pasini,Gaetano Gargiulo,Chantal Beekman,Kim Theilgaard-Mönch,Saverio Minucci,Bo T. Porse,Jean-Christophe Marine,Klaus Hansen,Kristian Helin +11 more
TL;DR: The ability of the oncogene BMI1 to repress the INK4A-ARF locus requires its direct association and is dependent on the continued presence of the EZH2-containing Polycomb-Repressive Complex 2 (PRC2) complex.
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Bone Marrow-Derived Macrophages (BMM): Isolation and Applications
TL;DR: A test for the phagocytic efficiency of BMMs by exposing them to fluorescently labeled yeast zymosan bioparticles is described and a method to deliver DNA or small interfering RNAs into these hard-to-transfect cells is described.
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Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
TL;DR: Activation of canonical Wnt signaling through conditional expression of a stable form of β-catenin causes multilineage differentiation block and compromised hematopoietic stem cell maintenance.
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EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas
Faizaan Mohammad,Simon Weissmann,Benjamin Leblanc,Deo Prakash Pandey,Jonas W. Højfeldt,Itys Comet,Chunqin Zheng,Jens Vilstrup Johansen,Nicolas Rapin,Bo T. Porse,Andrey Tvardovskiy,Andrey Tvardovskiy,Ole N. Jensen,Ole N. Jensen,Nagore G. Olaciregui,Cinzia Lavarino,Mariona Suñol,Carmen de Torres,Jaume Mora,Angel M. Carcaboso,Kristian Helin +20 more
TL;DR: Results show that residual PRC2 activity is required for the proliferation of H3K27M-expressing DIPGs, and that inhibition of EZH2 is a potential therapeutic strategy for the treatment of these tumors.
Journal ArticleDOI
E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo.
Bo T. Porse,Thomas Åskov Pedersen,Xiufeng Xu,Bo Lindberg,Ulla M. Wewer,Lennart Friis-Hansen,Claus Nerlov +6 more
TL;DR: It is shown that E2F repression by C/EBPalpha is critical for its ability to induce terminal differentiation, and thus genetic evidence that direct cell cycle control by a mammalian lineage-instructive transcription factor couples cellular growth arrest and differentiation is provided.