R.C. Sam

TL;DR: Obesity appears to be associated with thrombosis via several mechanisms that are all improved by weight loss, including the actions of so-called adipocytokines from adipose tissue.

TL;DR: The true incidence and, most importantly, natural history of such injuries are poorly described, meaning that surgeons have limited information to pass on to their patients and that the questions most frequently posed to ‘expert witnesses’ in medico-legal cases are difficult to answer with authority.

TL;DR: Patients with VV, and particularly CVU, have significantly higher prevalences of single and multiple thrombophilias than age- and sex-matched controls without clinical or duplex evidence of lower limb venous disease, and this data support the hypothesis that thROMbophilia predisposes to the development of superficial and deep lower limb Venous reflux.

TL;DR: Ulasound-guided foam sclerotherapy for great and small saphenous varicose veins leads to significant improvements in generic and disease-specific HRQOL for at least 12 months after treatment.

TL;DR: Hyperhomocysteinemia is common in patients with chronic venous insufficiency, especially those with ulceration, however, inasmuch as fewer than a third of patients with HHcy were C677T MTHFR homozygous or had vitamin B(12) or folate deficiency, other mechanisms must be responsible in the majority.