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R.J. Aitken
Researcher at Newcastle University
Publications - 15
Citations - 1149
R.J. Aitken is an academic researcher from Newcastle University. The author has contributed to research in topics: Sperm & DNA damage. The author has an hindex of 12, co-authored 15 publications receiving 890 citations. Previous affiliations of R.J. Aitken include IT University & University of Newcastle.
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Reactive oxygen species as mediators of sperm capacitation and pathological damage
TL;DR: Extensive evaluation of antioxidants that protect the spermatozoa against oxidative stress while permitting the normal reduction‐oxidation regulation of sperm capacitation is therefore currently being undertaken, and has already proven efficacious in animal models.
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Development of a novel electrophoretic system for the isolation of human spermatozoa.
TL;DR: Electrophoretic separation represents a highly effective, novel approach for the isolation of spermatozoa for assisted conception purposes and generated cells with significantly less DNA damage.
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Oxidative stress and human spermatozoa: diagnostic and functional significance of aldehydes generated as a result of lipid peroxidation
Ryan Moazamian,Ashley Polhemus,Haley Connaughton,Barbara Fraser,Sara Whiting,Parviz Gharagozloo,R.J. Aitken +6 more
TL;DR: This study examines the impact of a range of small molecular mass aldehydes generated as a consequence of lipid peroxidation on human sperm function and compares the two most commonly formed compounds, 4-hydroxynonenal (4HNE) and malondialdehyde (MDA), for their relative ability to reflect a state of oxidative stress in these cells.
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The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies
TL;DR: The origins of DNA damage in human spermatozoa, the methods that are available to monitor this aspect of semen quality and the clinical significance of such measurements are discussed in this paper.
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Potential importance of transition metals in the induction of DNA damage by sperm preparation media
R.J. Aitken,J.M. Finnie,L. Muscio,Sara Whiting,H.S. Connaughton,L. Kuczera,Tony Rothkirch,G. N. De Iuliis +7 more
TL;DR: The results explain why the preparation of spermatozoa on discontinuous colloidal silicon gradients can result in oxidative DNA damage and provide strategies for its prevention.