Reactive oxygen species as mediators of sperm capacitation and pathological damage
TLDR
Extensive evaluation of antioxidants that protect the spermatozoa against oxidative stress while permitting the normal reduction‐oxidation regulation of sperm capacitation is therefore currently being undertaken, and has already proven efficacious in animal models.Abstract:
Oxidative stress plays a major role in the life and death of mammalian spermatozoa. These gametes are professional generators of reactive oxygen species (ROS), which appear to derive from three potential sources: sperm mitochondria, cytosolic L-amino acid oxidases, and plasma membrane Nicotinamide adenine dinucleotide phosphate oxidases. The oxidative stress created via these sources appears to play a significant role in driving the physiological changes associated with sperm capacitation through the stimulation of a cyclic adenosine monophosphate/Protein kinase A phosphorylation cascade, including the activation of Extracellular signal regulated kinase-like proteins, massive up-regulation of tyrosine phosphorylation in the sperm tail, as well as the induction of sterol oxidation. When generated in excess, however, ROS can induce lipid peroxidation that, in turn, disrupts membrane characteristics that are critical for the maintenance of sperm function, including the capacity to fertilize an egg. Furthermore, the lipid aldehydes generated as a consequence of lipid peroxidation bind to proteins in the mitochondrial electron transport chain, triggering yet more ROS generation in a self-perpetuating cycle. The high levels of oxidative stress created as a result of this process ultimately damage the DNA in the sperm nucleus; indeed, DNA damage in the male germ line appears to be predominantly induced oxidatively, reflecting the vulnerability of these cells to such stress. Extensive evaluation of antioxidants that protect the spermatozoa against oxidative stress while permitting the normal reduction-oxidation regulation of sperm capacitation is therefore currently being undertaken, and has already proven efficacious in animal models.read more
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Journal ArticleDOI
Oxidative stress and sperm function: A systematic review on evaluation and management
TL;DR: OS is an important cause of male factor infertility and its assessment provides essential information that can guide treatment strategies aimed at improving the male’s reproductive potential.
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Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
Ashok Agarwal,Neel Parekh,Manesh Kumar Panner Selvam,Ralf Henkel,Ralf Henkel,Rupin Shah,Sheryl T. Homa,Ranjith Ramasamy,Edmund Y. Ko,Kelton Tremellen,Sandro C. Esteves,Sandro C. Esteves,Ahmad Majzoub,Ahmad Majzoub,Juan G. Alvarez,David K. Gardner,Channa N. Jayasena,Channa N. Jayasena,Jonathan Ramsay,Chak-Lam Cho,Ramadan A Saleh,Denny Sakkas,James M. Hotaling,Scott Lundy,Sarah C. Vij,Joel L. Marmar,Jaime Gosálvez,Edmund Sabanegh,Hyun Jun Park,Armand Zini,Parviz Kavoussi,Sava Micic,Ryan P. Smith,Gian Maria Busetto,Mustafa Emre Bakircioglu,Gerhard Haidl,Giancarlo Balercia,Nicolás Garrido Puchalt,Moncef Ben-Khalifa,Nicholas N. Tadros,Jackson Kirkman-Browne,Sergey I. Moskovtsev,Xuefeng Huang,Edson Borges,Daniel R. Franken,Natan Bar-Chama,Yoshiharu Morimoto,Kazuhisa Tomita,Vasan Satya Srini,Willem Ombelet,Elisabetta Baldi,Monica Muratori,Yasushi Yumura,Sandro La Vignera,Raghavender Kosgi,Marlon Martinez,Donald P. Evenson,Daniel Suslik Zylbersztejn,Matheus Roque,Marcello Cocuzza,Marcelo Vieira,Assaf Ben-Meir,Raoul Orvieto,Raoul Orvieto,Eliahu Levitas,Amir Wiser,Amir Wiser,Mohamed Arafa,Vineet Malhotra,Sijo Parekattil,Haitham Elbardisi,Luiz Carvalho,Rima Dada,Christophe Sifer,Pankaj Talwar,Ahmet Gudeloglu,Ahmed M A Mahmoud,Khaled Terras,Chadi Yazbeck,Bojanic Nebojsa,Damayanthi Durairajanayagam,Ajina Mounir,Linda G. Kahn,Saradha Baskaran,Rishma Pai,Donatella Paoli,Kristian Leisegang,Mohamed Reza Moein,Sonia Malik,Önder Yaman,Luna Samanta,Fouad Bayane,Sunil Jindal,Muammer Kendirci,Barış Altay,Dragoljub Perovic,Avi Harlev +96 more
TL;DR: Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants) and may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose.
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Role of oxidative stress, infection and inflammation in male infertility.
Ashok Agarwal,Mohit Rana,Emily Qiu,Hashem AlBunni,Albert D. Bui,Albert D. Bui,Ralf Henkel,Ralf Henkel +7 more
TL;DR: This review is focusing on infection and inflammation‐mediated OS, the inflammatory markers underlying pathology, clinical significance in male infertility, and a brief description of the recommended treatment modalities.
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POHaD: why we should study future fathers.
TL;DR: A better understanding of pre-conceptional origins of disease through the paternal exposome will be informative to the field of transgenerational epigenetics and will ultimately help instruct and guide public health policies in the future.
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Cellular responses of Pacific oyster (Crassostrea gigas) gametes exposed in vitro to polystyrene nanoparticles
Carmen González-Fernández,Kevin Tallec,Nelly Le Goïc,Christophe Lambert,Philippe Soudant,Arnaud Huvet,Marc Suquet,Mathieu Berchel,Ika Paul-Pont +8 more
TL;DR: The results demonstrate that the effects of NPs occur rapidly, are complex and are possibly associated with the cellular eco-corona, which could modify NPs behaviour and toxicity.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
Elizabeth Yang,Jiping Zha,Jennifer Jockel,Lawrence H. Boise,Craig B. Thompson,Stanley J. Korsmeyer +5 more
TL;DR: A novel interacting protein, Bad, whose homology to Bcl-2 is limited to the BH1 and BH2 domains is identified, whose role in the mammalian cell death pathway is determined by these competing dimerizations in which levels of Bad influence the effectiveness of BCl-2 versus B cl-xL in repressing death.
Journal ArticleDOI
Fertilizing Capacity of Spermatozoa deposited into the Fallopian Tubes
TL;DR: The following experiment demonstrates that such a period of time in the female tract is required for the spermatozoa to acquire their fertilizing capacity.
Journal ArticleDOI
Generation of reactive oxygen species, lipid peroxidation, and human sperm function.
TL;DR: Results are consistent with a causative role for lipid peroxidation in the etiology of defective sperm function and also suggest a possible physiological role for the reactive oxygen species generated by human spermatozoa in mediating sperm-zona interaction.
Journal ArticleDOI
Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa.
TL;DR: Studies with scavengers of reactive oxygen species revealed that, while reagents directed against singlet oxygen and the hydroxyl radical were without effect, cytochrome C reduced the response to A23187 by about 50%, suggesting that the superoxide anion radical is a major product of the activated human spermatozoon.