R
R. J. Motekaitis
Researcher at Washington University in St. Louis
Publications - 13
Citations - 599
R. J. Motekaitis is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Stability constants of complexes & Chelation. The author has an hindex of 10, co-authored 13 publications receiving 572 citations.
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Journal ArticleDOI
Radiolabeling and In Vivo Behavior of Copper-64-Labeled Cross-Bridged Cyclam Ligands
Xiankai Sun,Melinda Wuest,Gary R. Weisman,Edward H. Wong,David P. Reed,C. Andrew Boswell,R. J. Motekaitis,Arthur E. Martell,Michael J. Welch,Carolyn J. Anderson +9 more
TL;DR: The rapid clearance of the (64)Cu-2 complex from the blood and liver, as well as liver metabolism experiments in rats, suggests that it is highly stable in vivo, and a bifunctional chelator of 2 is a significant candidate for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy.
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Indium (III) and gallium (III) complexes of bis(aminoethanethiol) ligands with different denticities: stabilities, molecular modeling, and in vivo behavior.
Yizhen Sun,Carolyn J. Anderson,Tammy S. Pajeau,David E. Reichert,Robert D. Hancock,R. J. Motekaitis,and Arthur E. Martell,Michael J. Welch +7 more
TL;DR: The 67/68Ga- and 111In-ligand complexes with more donor atoms showed were more stable in serum, both in vitro and in vivo, and the effects of the gem-dimethyl groups on complex stabilities are explained by molecular modeling.
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Stability and Structure of Activated Macrocycles. Ligands with Biological Applications.
TL;DR: The protonation constants, stability constants, and pM's are discussed in terms of both molecular mechanics calculations and the ligands' potential applicability as copper(II) radiopharmaceuticals.
Journal ArticleDOI
The Gallium(III) and Indium(III) Complexes of Tris(2-mercaptobenzyl)amine and Tris(2-hydroxybenzyl)amine
R. J. Motekaitis,Arthur E. Martell,Stephen A. Koch,JungWon Hwang,Duncan A. Quarless,Michael J. Welch +5 more
TL;DR: Tris(2-mercaptobenzyl)amine, S3N, and tris(2hydroxybenzyl)amines, O3N were investigated with In3+ and Ga3+ in solution and in the solid state to help interpret the contrasting in vivo behavior of...