R
R. James Swanson
Researcher at Old Dominion University
Publications - 27
Citations - 1729
R. James Swanson is an academic researcher from Old Dominion University. The author has contributed to research in topics: Human fertilization & Apoptosis. The author has an hindex of 14, co-authored 25 publications receiving 1614 citations. Previous affiliations of R. James Swanson include College of Osteopathic Medicine of the Pacific & Eastern Virginia Medical School.
Papers
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Journal ArticleDOI
Nanosecond pulsed electric fields cause melanomas to self-destruct
Richard Nuccitelli,Uwe Pliquett,Xinhua Chen,Wentia Ford,R. James Swanson,Stephen J. Beebe,Stephen J. Beebe,Juergen F. Kolb,Karl H. Schoenbach +8 more
TL;DR: It is shown that 40 kV/cm electric field pulses 300 nanoseconds in duration can rapidly stimulate pyknosis, reduce blood flow and fragment DNA in murine melanoma tumors in vivo with a total field exposure time of 1.8 microseconds.
Journal ArticleDOI
New method of evaluating sperm morphology with predictive value for human in vitro fertilization
Thinus F. Kruger,Thinus F. Kruger,Thinus F. Kruger,Anibal A. Acosta,Anibal A. Acosta,Anibal A. Acosta,Kathryn F. Simmons,Kathryn F. Simmons,Kathryn F. Simmons,R. James Swanson,R. James Swanson,R. James Swanson,James F. Matta,James F. Matta,James F. Matta,Lucinda L. Veeck,Lucinda L. Veeck,Lucinda L. Veeck,Mahmood Morshedi,Mahmood Morshedi,Mahmood Morshedi,Santiago Brugo,Santiago Brugo,Santiago Brugo +23 more
TL;DR: The value of analyzing sperm morphology using the criteria recommended in terms of predicting fertilization and perhaps pregnancy outcome is demonstrated and a trend is shown in the pregnancy rate that may indicate the importance of the male genome in establishing a pregnancy.
Journal ArticleDOI
A new pulsed electric field therapy for melanoma disrupts the tumor’s blood supply and causes complete remission without recurrence
Richard Nuccitelli,Xinhua Chen,Andrei G. Pakhomov,Wallace H. Baldwin,Saleh Sheikh,Jennifer L. Pomicter,Wei Ren,C. Osgood,R. James Swanson,Juergen F. Kolb,Stephen J. Beebe,Karl H. Schoenbach +11 more
TL;DR: The application of 300 high‐voltage (40 kV/cm), ultrashort (300 nsec) electrical pulses to murine melanomas in vivo triggers both necrosis and apoptosis, resulting in complete tumor remission within an average of 47 days in the 17 animals treated.
Journal ArticleDOI
Leukemic cell intracellular responses to nanosecond electric fields.
Nianyong Chen,Karl H. Schoenbach,Juergen F. Kolb,R. James Swanson,Allen L. Garner,Jing Yang,Ravindra P. Joshi,Stephen J. Beebe +7 more
TL;DR: High voltage, nsPEFs target the nucleus and modify cellular functions while plasma membrane effects are delayed and become smaller as pulse duration is shortened, suggesting application of this ultrashort pulse technology to modulate nuclear structure and function for potential therapeutic benefit.
Journal ArticleDOI
Age-Associated Metabolic and Morphologic Changes in Mitochondria of Individual Mouse and Hamster Oocytes
TL;DR: In this paper, the effects of aging on mitochondrial structure and energy production within the mammalian oocyte were examined in both young and old mice and hamsters, and it was shown that decreased adenosine triphosphate in aged oocytes is correlated with a similar decrease in mtDNA molecules and number of mitochondria.