R. L. Sutherland

TL;DR: The results indicate that upregulation of GATA-2 may contribute to the progression to aggressive prostate cancer through modulation of expression of AR and key androgen-regulated genes, one of which, AZGP1, is associated with the progression with metastatic disease.

TL;DR: Specific cyclin D1 isoforms are associated with discrete forms of breast cancer and high cyclinD1b protein levels hold prognostic potential, and cycl in D1b was particularly associated with poor outcome in the context of ER-negative breast cancer.

TL;DR: Although apo-D expression is androgen regulated in human breast cancer cell lines in vitro, its expression in primary breast cancers may be regulated by other factors, which suggests that the receptor may be involved in tumour responsiveness or in abnormal responses to endocrine therapies.

TL;DR: Patients aged ⩾70 are less likely to receive adjuvant therapy although it is associated with improved outcome, and increased use of adjuant therapy in older individuals is encouraged as they constitute a large proportion of patients with pancreatic cancer.

TL;DR: It is suggested that sFRP4 is an inhibitor of prostate cancer growth and invasion in vitro independent of androgen receptor (AR) signaling with correlative evidence in human androgen-dependent disease suggesting similar changes in the clinical setting.