S
Sandra A O'Toole
Researcher at Royal Prince Alfred Hospital
Publications - 175
Citations - 8998
Sandra A O'Toole is an academic researcher from Royal Prince Alfred Hospital. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 44, co-authored 166 publications receiving 6898 citations. Previous affiliations of Sandra A O'Toole include The Breast Cancer Research Foundation & University of Western Sydney.
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Journal ArticleDOI
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group Part 2 TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors
Shona Hendry,Roberto Salgado,Thomas Gevaert,Prudence A. Russell,Prudence A. Russell,Thomas John,Thomas John,Bibhusal Thapa,Michael Christie,Koen Van de Vijver,Monica V. Estrada,Paula I. Gonzalez-Ericsson,Melinda E. Sanders,Benjamin Solomon,Cinzia Solinas,Gert Van den Eynden,Yves Allory,Yves Allory,Matthias Preusser,Johannes A. Hainfellner,Giancarlo Pruneri,Andrea Vingiani,Sandra Demaria,Fraser Symmans,Paolo Nuciforo,Laura Comerma,E. A. Thompson,Sunil R. Lakhani,Sunil R. Lakhani,Seong Rim Kim,Stuart J. Schnitt,Cecile Colpaert,Christos Sotiriou,Stefan J. Scherer,Michail Ignatiadis,Sunil S. Badve,Robert H. Pierce,Giuseppe Viale,Nicolas Sirtaine,Frédérique Penault-Llorca,Tomohagu Sugie,Susan Fineberg,Soonmyung Paik,Ashok Srinivasan,Andrea L. Richardson,Yihong Wang,Yihong Wang,Ewa Chmielik,Jane E. Brock,Douglas B. Johnson,Justin M. Balko,Stephan Wienert,Veerle Bossuyt,Stefan Michiels,Nils Ternès,Nicole Burchardi,Stephen J Luen,Stephen J Luen,Peter Savas,Peter Savas,Frederick Klauschen,Peter H. Watson,Peter H. Watson,Brad H. Nelson,Brad H. Nelson,Carmen Criscitiello,Sandra A O'Toole,Denis Larsimont,Roland de Wind,Giuseppe Curigliano,Fabrice Andre,Magali Lacroix-Triki,Mark van de Vijver,Federico Rojo,Giuseppe Floris,Shahinaz Bedri,Joseph A. Sparano,David L. Rimm,Torsten O. Nielsen,Zuzana Kos,Stephen M. Hewitt,Baljit Singh,Gelareh Farshid,Gelareh Farshid,Sibylle Loibl,Kimberly H. Allison,Nadine Tung,Sylvia Adams,Karen Willard-Gallo,Hugo M. Horlings,Leena Gandhi,Leena Gandhi,Andre L. Moreira,Fred R. Hirsch,Maria Vittoria Dieci,Maria Urbanowicz,Iva Brcic,Konstanty Korski,Fabien Gaire,Hartmut Koeppen,Amy C. Y. Lo,Amy C. Y. Lo,Jennifer M. Giltnane,Marlon Rebelatto,Keith Steele,Jiping Zha,Kenneth Emancipator,Jonathan Juco,Carsten Denkert,Jorge S. Reis-Filho,Sherene Loi,Stephen B. Fox +111 more
TL;DR: Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.
Journal ArticleDOI
Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research
Shona Hendry,Roberto Salgado,Thomas Gevaert,Prudence A. Russell,Prudence A. Russell,Thomas John,Thomas John,Bibhusal Thapa,Michael Christie,Koen Van de Vijver,Monica V. Estrada,Paula I. Gonzalez-Ericsson,Melinda E. Sanders,Benjamin sss Solomon,Cinzia Solinas,Gert Van den Eynden,Yves Allory,Yves Allory,Matthias Preusser,Johannes A. Hainfellner,Giancarlo Pruneri,Andrea Vingiani,Sandra Demaria,Fraser Symmans,Paolo Nuciforo,Laura Comerma,E. A. Thompson,Sunil R. Lakhani,Sunil R. Lakhani,Seong-Rim Kim,Stuart J. Schnitt,Cecile Colpaert,Christos Sotiriou,Stefan J. Scherer,Michail Ignatiadis,Sunil Badve,Robert H. Pierce,Giuseppe Viale,Nicolas Sirtaine,Frédérique Penault-Llorca,Tomohagu Sugie,Susan Fineberg,Soonmyung Paik,Ashok Srinivasan,Andrea L. Richardson,Yihong Wang,Yihong Wang,Ewa Chmielik,Jane E. Brock,Douglas B. Johnson,Justin M. Balko,Stephan Wienert,Veerle Bossuyt,Stefan Michiels,Nils Ternès,Nicole Burchardi,Stephen J Luen,Stephen J Luen,Peter Savas,Peter Savas,Frederick Klauschen,Peter H. Watson,Brad H. Nelson,Carmen Criscitiello,Sandra A O'Toole,Denis Larsimont,Roland de Wind,Giuseppe Curigliano,Fabrice Andre,Magali Lacroix-Triki,Mark van de Vijver,Federico Rojo,Giuseppe Floris,Shahinaz Bedri,Joseph A. Sparano,David L. Rimm,Torsten O. Nielsen,Zuzana Kos,Stephen M. Hewitt,Baljit Singh,Gelareh Farshid,Sibylle Loibl,Kimberly H. Allison,Nadine Tung,Sylvia Adams,Karen Willard-Gallo,Hugo M. Horlings,Leena Gandhi,Leena Gandhi,Andre L. Moreira,Fred R. Hirsch,Maria Vittoria Dieci,Maria Urbanowicz,Iva Brcic,Konstanty Korski,Fabien Gaire,Hartmut Koeppen,Amy C. Y. Lo,Amy C. Y. Lo,Jennifer M. Giltnane,Marlon Rebelatto,Keith Steele,Jiping Zha,Kenneth Emancipator,Jonathan Juco,Carsten Denkert,Jorge S. Reis-Filho,Sherene Loi,Stephen B. Fox +108 more
TL;DR: In this paper, a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, was proposed.
Journal ArticleDOI
ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
M van Geldermalsen,M van Geldermalsen,Qian Wang,Qian Wang,Rajini Nagarajah,Rajini Nagarajah,Amy D. Marshall,Amy D. Marshall,Annora Thoeng,Annora Thoeng,Dadi Gao,Dadi Gao,William Ritchie,William Ritchie,Yue Feng,Yue Feng,Charles G. Bailey,Charles G. Bailey,Niantao Deng,Niantao Deng,Kate Harvey,Kate Harvey,Jane Beith,C.I. Selinger,Sandra A O'Toole,Sandra A O'Toole,Sandra A O'Toole,John E.J. Rasko,John E.J. Rasko,John E.J. Rasko,Jeff Holst,Jeff Holst +31 more
TL;DR: Preclinical evidence for the feasibility of novel therapies exploiting ASCT2 transporter activity in breast cancer is provided, particularly in the high-risk basal-like subgroup of TN breast cancer where there is not only high expression of AsCT2, but also a marked reliance on its activity for sustained cellular proliferation.
Journal ArticleDOI
Prediction of Local Recurrence, Distant Metastases, and Death After Breast-Conserving Therapy in Early-Stage Invasive Breast Cancer Using a Five-Biomarker Panel
Ewan K.A. Millar,Peter Graham,Sandra A O'Toole,Catriona M. McNeil,Lois Browne,Adrienne Morey,Sarah A. Eggleton,Julia Beretov,Con Theocharous,Anne Capp,Elias H. Nasser,John H. Kearsley,Geoffrey P Delaney,George Papadatos,C Fox,Robert L. Sutherland +15 more
TL;DR: Although this approach provides additional information to predict time to IBTR, LRR, DDFS, and death from breast cancer, its predictive power is less than that of traditional pathologic indices.
Journal ArticleDOI
A single-cell and spatially resolved atlas of human breast cancers.
Sunny Z. Wu,Sunny Z. Wu,Ghamdan Al-Eryani,Ghamdan Al-Eryani,Daniel L. Roden,Daniel L. Roden,Simon Junankar,Simon Junankar,Kate Harvey,Alma Andersson,Aatish Thennavan,Chenfei Wang,James R. Torpy,James R. Torpy,Nenad Bartonicek,Nenad Bartonicek,Taopeng Wang,Taopeng Wang,Ludvig Larsson,Dominik C. Kaczorowski,Neil I. Weisenfeld,Cedric Uytingco,Jennifer Chew,Zachary Bent,Chia-Ling Chan,Vikkitharan Gnanasambandapillai,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Laurence Gluch,Mun N. Hui,Jane Beith,Andrew Parker,Andrew Parker,Elizabeth Robbins,Davendra Segara,Caroline Cooper,Caroline Cooper,Cindy Mak,Belinda Chan,Sanjay Warrier,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux,Ewan K.A. Millar,Ewan K.A. Millar,Ewan K.A. Millar,Joseph E. Powell,Joseph E. Powell,Stephen R. Williams,X. Shirley Liu,Sandra A O'Toole,Elgene Lim,Elgene Lim,Elgene Lim,Joakim Lundeberg,Charles M. Perou,Alexander Swarbrick,Alexander Swarbrick +57 more
TL;DR: In this paper, a single-cell and spatially resolved transcriptomics analysis of human breast cancers is presented, which reveals recurrent neoplastic cell heterogeneity and heterotypic interactions play central roles in disease progression.