R. M. Sharpe

TL;DR: The findings suggest that the main actions of oestrogens in the male reproductive tract, mediated by ER alpha, are related to the development and function of the efferent ducts and the Leydig cells.

TL;DR: Data from DES and GnRHa treatments are interpreted as providing evidence for direct modulation of Sertoli cell (maturational) development by DES, and testis weight and daily sperm production were reduced in adulthood, but spermatogenesis was grossly normal.

TL;DR: To identify potential androgen-regulated proteins (ARP) that might mediate the supportive effects of testosterone on spermatogenesis, long seminiferous tubule segments were isolated from control rats and from EDS-treated rats (+/- TE-supplementation) at stages II-V, VI-VIII, or IX-XII, 2 days to 6 days after EDS treatment.

TL;DR: It is suggested that many of the adverse changes to the testis and reproductive tract induced by exposure to oestrogens result from a combination of high oestrogen and low androgen action.

TL;DR: It is concluded that reproductive tract abnormalities induced in the neonatal male rat by a high (10 microg) dose of DES are associated with reduced AR expression and Leydig cell volume, and these changes are largely absent with a lower dose ofDES.