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Nina Atanassova
Researcher at Bulgarian Academy of Sciences
Publications - 60
Citations - 3845
Nina Atanassova is an academic researcher from Bulgarian Academy of Sciences. The author has contributed to research in topics: Spermatogenesis & Sertoli cell. The author has an hindex of 25, co-authored 57 publications receiving 3590 citations. Previous affiliations of Nina Atanassova include Medical Research Council.
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Journal ArticleDOI
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.
Karel De Gendt,Johannes V. Swinnen,Philippa T. K. Saunders,Luc Schoonjans,Mieke Dewerchin,Ann Devos,Karen Tan,Nina Atanassova,Frank Claessens,Charlotte Lécureuil,Walter Heyns,Peter Carmeliet,Florian Guillou,Richard M. Sharpe,Guido Verhoeven +14 more
TL;DR: It is concluded that cell-autonomous action of the AR in SC is an absolute requirement for androgen maintenance of complete spermatogenesis, and that sPermatocyte/spermatid development/survival critically depends on androgens.
Journal ArticleDOI
Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels.
Nina Atanassova,Chris McKinnell,K. J. Turner,M. Walker,Jane S. Fisher,M Morley,Michael Millar,N. P. Groome,Richard M. Sharpe +8 more
TL;DR: It is concluded that neonatal exposure of rats to low levels of estrogens can advance the first wave of spermatogenesis at puberty, although it is unclear whether this is due to direct effects of the estrogen or to associated elevation of FSH levels.
Journal ArticleDOI
Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood.
Nina Atanassova,Chris McKinnell,M. Walker,K. J. Turner,Jane S. Fisher,M Morley,Michael Millar,Nigel P. Groome,Richard M. Sharpe +8 more
TL;DR: It is concluded that neonatal estrogen treatment results in dose-dependent alterations in Sertoli cell numbers, germ cell volume, efficiency of spermatogenesis, and germ cell apoptosis in adulthood, and elevated FSH levels in adulthood may improve the efficiency of
Journal ArticleDOI
Androgen action via testicular peritubular myoid cells is essential for male fertility
TL;DR: This study provides the first direct evidence for the importance of androgen‐driven stromal‐epithelial interactions underpinning the regulation of spermatogenesis and PTM‐ARKO mice will enable identification of the new molecular pathways involved.
Journal ArticleDOI
The Role of Androgens in Sertoli Cell Proliferation and Functional Maturation: Studies in Mice with Total or Sertoli Cell-Selective Ablation of the Androgen Receptor
Karen A. L. Tan,Karel De Gendt,Nina Atanassova,Marion F Walker,Richard M. Sharpe,Philippa T. K. Saunders,Evi Denolet,Guido Verhoeven +7 more
TL;DR: Androgen action is not required for maturation-dependent changes in immunoexpression of the SC markers AMH, p27(kip1), GATA-1, and sulfated glycoprotein-2 but is essential for expression of other SC genes, the attainment of normal SC number, and the support of meiotic and postmeiotic germ cell development.