R
R. Michael Blaese
Researcher at National Institutes of Health
Publications - 117
Citations - 9336
R. Michael Blaese is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Antibody & Genetic enhancement. The author has an hindex of 40, co-authored 117 publications receiving 9086 citations. Previous affiliations of R. Michael Blaese include Baylor College of Medicine & Government of the United States of America.
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Journal ArticleDOI
T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years
R. Michael Blaese,Kenneth W. Culver,A. Dusty Miller,Charles S. Carter,Thomas A. Fleisher,Mario Clerici,Gene M. Shearer,Lauren A. Chang,Yawen Chiang,Paul Tolstoshev,Jay J. Greenblatt,Steven A. Rosenberg,Harvey G. Klein,Melvin Berger,Craig A. Mullen,W. Jay Ramsey,Linda M. Muul,Richard A. Morgan,W. French Anderson +18 more
TL;DR: In this article, a clinical trial was started using retroviral-mediated transfer of the ADA gene into the T cells of two children with severe combined immunodeficiency (ADA-SCID).
Journal ArticleDOI
Gene Transfer into Humans — Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction
Steven A. Rosenberg,Paul Aebersold,Kenneth Cornetta,Attan Kasid,Richard A. Morgan,Robert C. Moen,Karson E,Michael T. Lotze,James Chih-Hsin Yang,Suzanne L. Topalian,Maria J. Merino,Kenneth W. Culver,A. Dusty Miller,R. Michael Blaese,W. French Anderson +14 more
TL;DR: These studies demonstrate the feasibility and safety of using retroviral gene transduction for human gene therapy and have implications for the design of TIL with improved antitumor potency, as well as for the possible use of lymphocytes for the gene therapy of other diseases.
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A multiinstitutional survey of the Wiskott-Aldrich syndrome
TL;DR: It is concluded that many patients with Wiskott-Aldrich syndrome have an atypical presentation and that a panel of diagnostic tests is often required to establish the diagnosis.
Journal ArticleDOI
Improved methods of retroviral vector transduction and production for gene therapy.
Hitoshi Kotani,Perry Newton,Shuyuan Zhang,Yawen L. Chiang,Edward Otto,L. H. Weaver,R. Michael Blaese,W. French Anderson,Gerard J. McGarrity +8 more
TL;DR: In studies on transduction by retroviral vectors, centrifugation of vector supernatants onto target cells significantly increased transduction efficiency as measured by vector titration for G418 resistance, fluorescence-activated cell sorting (FACS), and polymerase chain reaction (PCR) analyses.
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Gene therapy for cancer
TL;DR: Direct approaches to the treatment of cancer by gene therapy include the augmentation of the immune system; direct approaches include restoration of the normal function of a mutated tumor suppressor gene or expression of a tumoricidal gene.