R. Paul Maguire

TL;DR: Results showed a 20‐ and 35‐fold increase in extracellular 5‐HT levels in the prefrontal cortex after injection of FEN at a dose of 5 mg/kg and 10mg/kg respectively, but no differences in BP were found between the control and FEN scans, which may imply that the majority of 5‐ HT1A receptors is in the low affinity state in the living brain.

TL;DR: This study demonstrated that [(11)C]MRB is suitable for drug occupancy studies of NET, and caudate was found to be the most suitable for preclinical drug occupancy Studies in rhesus monkeys.

TL;DR: It is suggested that the combined MP challenge with functional imaging, as described in this study, may be a useful tool to study the functional integrity of the dopaminergic system in psychiatric disorders.

TL;DR: It is suggested that studies of whole-brain cerebral metabolism may be useful for studying glycine-related mechanisms in healthy humans because there is not a clear cognitive or behavioral signal related to glycine administration at doses thought to be important clinically in patient populations.

TL;DR: In this paper , a nonlinear model was developed to estimate the brain entry rate of antiepileptic drugs, including levetiracetam (LEV) and brivaracetam(BRV), based on the displacement of SV2A tracer 11C-UCB-J.