Yiyun Huang

TL;DR: In this article, D1 receptor availability was measured with positron emission tomography and the selective D 1 receptor antagonist NCL 112 in 16 patients with schizophrenia (seven drug-naive and nine drug-free patients) and 16 matched healthy controls.

TL;DR: Serotonin-1A receptor BP is abnormally decreased in the depressed phase of familial mood disorders in multiple brain regions and may be associated with histopathological changes involving the raphe, convergence evidence from postmortem studies of mood disorders suggests.

TL;DR: The demonstration of an appropriate accuracy and precision of D2 receptor measurement with [11C]raclopride in the VST is the first critical step toward the use of this ligand in the study of synaptic dopamine transmission at D2 receptors in theVST using endogenous competition techniques.

TL;DR: Results show significant differences in the dopamine response to amphetamine between the functional subdivisions of the human striatum, which may be related to the asymmetrical feed-forward influences mediating the integration of limbic, cognitive, and sensorimotor striatal function via dopamine cell territories in the ventral midbrain.

TL;DR: These findings suggest that schizophrenia is associated with elevated dopamine function in associative regions of the striatum, and suggests that elevated subcortical dopamine function might adversely affect performance of the dorsolateral prefrontal cortex in schizophrenia.