M
Mika Naganawa
Researcher at Yale University
Publications - 126
Citations - 3183
Mika Naganawa is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Positron emission tomography. The author has an hindex of 26, co-authored 116 publications receiving 2171 citations. Previous affiliations of Mika Naganawa include University of Tokyo & National Institute of Radiological Sciences.
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Journal ArticleDOI
Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging.
Ming-Kai Chen,Adam P. Mecca,Mika Naganawa,Sjoerd J. Finnema,Takuya Toyonaga,Shu-fei Lin,Soheila Najafzadeh,Jim Ropchan,Yihuan Lu,Julia W. McDonald,Hannah R. Michalak,Nabeel Nabulsi,Amy F.T. Arnsten,Yiyun Huang,Richard E. Carson,Christopher H. van Dyck +15 more
TL;DR: This approach may provide a direct measure of synaptic density, and it therefore holds promise as an in vivo biomarker for AD and as an outcome measure for trials of disease-modifying therapies, particularly those targeted at the preservation and restoration of synapses.
Journal ArticleDOI
Lower synaptic density is associated with depression severity and network alterations.
Sophie E. Holmes,Dustin Scheinost,Sjoerd J. Finnema,Mika Naganawa,Margaret T. Davis,Nicole DellaGioia,Nabeel Nabulsi,David Matuskey,Gustavo A. Angarita,Robert H. Pietrzak,Robert H. Pietrzak,Ronald S. Duman,Gerard Sanacora,John H. Krystal,John H. Krystal,Richard E. Carson,Irina Esterlis,Irina Esterlis +17 more
TL;DR: This is the first in vivo evidence linking lower synaptic density to network alterations and symptoms of depression, and provides further incentive to evaluate interventions that restore synaptic connections to treat depression.
Journal ArticleDOI
PET kinetic analysis --- compartmental model
TL;DR: This review describes the principle of the compartmental model and categorizes the techniques and approaches for the compartmentAL model according to various aspects: model design, experimental design, invasiveness, and mathematical solution.
Journal ArticleDOI
In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET
Adam P. Mecca,Ming-Kai Chen,Ryan S. O'Dell,Mika Naganawa,Takuya Toyonaga,Tyler A. Godek,Joanna E. Harris,Hugh H. Bartlett,Wenzhen Zhao,Nabeel Nabulsi,Brent C. Vander Wyk,Pradeep Varma,Amy F.T. Arnsten,Yiyun Huang,Richard E. Carson,Christopher H. van Dyck +15 more
TL;DR: PET imaging of synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising biomarker of synaptic density in Alzheimer's disease.
Journal ArticleDOI
Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients
Masahiro Mishina,Kiichi Ishiwata,Mika Naganawa,Yuichi Kimura,Shin Kitamura,Masahiko Suzuki,Masaya Hashimoto,Kenji Ishibashi,Keiichi Oda,Muneyuki Sakata,Makoto Hamamoto,Shiro Kobayashi,Yasuo Katayama,Kenji Ishii +13 more
TL;DR: It is suggested that the A2ARs in the putamen compensate for the asymmetrical decrease of dopamine in drug-naïve PD patients and that antiparkinsonian therapy increases the A1A receptors in thePutamen.