R
R. Sathish Srinivasan
Researcher at Oklahoma Medical Research Foundation
Publications - 47
Citations - 3323
R. Sathish Srinivasan is an academic researcher from Oklahoma Medical Research Foundation. The author has contributed to research in topics: Lymphatic system & Lymphatic Endothelium. The author has an hindex of 23, co-authored 43 publications receiving 2709 citations. Previous affiliations of R. Sathish Srinivasan include University of Oklahoma & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
Natasha L. Harvey,R. Sathish Srinivasan,Miriam E. Dillard,Nicole C. Johnson,Marlys H. Witte,Kelli Boyd,Mark W. Sleeman,Guillermo Oliver +7 more
TL;DR: It is found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels.
Journal ArticleDOI
Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature
R. Sathish Srinivasan,Miriam E. Dillard,Oleg Lagutin,Fu-Jung Lin,Sophia Y. Tsai,Ming-Jer Tsai,Igor M. Samokhvalov,Guillermo Oliver +7 more
TL;DR: From venous-derived lymph sacs, lymphatic endothelial cells sprouted, proliferated, and migrated to give rise to the entire lymphatic vasculature, and that hematopoietic cells did not contribute to the developing lymph sacS.
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The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells
R. Sathish Srinivasan,Xin Geng,Ying Yang,Yingdi Wang,Suraj Mukatira,Michèle Studer,Marianna P.R. Porto,Oleg Lagutin,Guillermo Oliver +8 more
TL;DR: It is demonstrated that the nuclear hormone receptor Coup-TFII is necessary for the activation of Prox1 in embryonic veins by directly binding a conserved DNA domain in the regulatory region ofprox1.
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Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos
Ying Yang,José Manuel García-Verdugo,Mario Soriano-Navarro,R. Sathish Srinivasan,Joshua P. Scallan,Manvendra K. Singh,Jonathan A. Epstein,Guillermo Oliver +7 more
TL;DR: It is determined that LECs leave the CV by an active budding mechanism, and that Prox1 activity is necessary for LEC progenitors to exit the CV.
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Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves
TL;DR: The embryonic lymphovenous valves controlling this vital communication are characterized and it is shown that they are formed by the intercalation of lymphatic endothelial cells (LECs) with a subpopulation of venous endothelial Cells (ECs) at the junction of the jugular and subclavian veins.