Rachel L. Damico

TL;DR: RV contractile reserve is depressed in SSc-PAH versus IPAH subjects, associated with reduced calcium recycling during exercise, and RV dilation during exercise can predict adverse ventricular-vascular coupling in PAH patients.

TL;DR: Up-front combination therapy with ambrisentan and tadalafil significantly improved hemodynamics, RV structure and function, and functional status in treatment-naive patients with SSc-PAH and may represent a very effective therapy for this patient population.

TL;DR: This large analysis investigating the prognostic value of DPG found an elevated DPG had no effect on post-transplant survival in patients with PH and an elevated TPG and PVR.

TL;DR: Serum ES correlated with poor functional status, decreased exercise tolerance, and invasive hemodynamics variables, and a loss-of-function, missense variant in the gene encoding ES, Col18a1, was linked to lower circulating protein and was independently associated with reduced mortality.

TL;DR: Pulmonary effective arterial elastance and pulmonary arterial compliance more consistently predicted mortality than pulmonary vascular resistance or transpulmonary gradient across a spectrum of left heart disease with pulmonary hypertension, including patients withHeart failure with preserved ejection fraction, heart failure with reduced ejection fractions, and pulmonary hypertension with a normal pulmonary vascular Resistance.