T
Todd M. Kolb
Researcher at Johns Hopkins University
Publications - 94
Citations - 1935
Todd M. Kolb is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pulmonary hypertension & Medicine. The author has an hindex of 22, co-authored 76 publications receiving 1386 citations. Previous affiliations of Todd M. Kolb include University of Maryland, Baltimore & Johns Hopkins University School of Medicine.
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Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement
Tim Lahm,Ivor S. Douglas,Stephen L. Archer,Harm Jan Bogaard,Naomi C. Chesler,Francois Haddad,Anna R. Hemnes,Steven M. Kawut,Jeffrey A. Kline,Todd M. Kolb,Stephen C. Mathai,Olaf Mercier,Evangelos D. Michelakis,Robert Naeije,Rubin M. Tuder,Corey E. Ventetuolo,Antoine Vieillard-Baron,Norbert F. Voelkel,Anton Vonk-Noordegraaf,Paul M. Hassoun +19 more
TL;DR: This document reviews the knowledge in the field of RV failure, identifies and prioritizes the most pertinent research gaps, and provides a prioritized pathway for addressing these preclinical and clinical questions.
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Right Ventricular Functional Reserve in Pulmonary Arterial Hypertension
Steven Hsu,Brian A. Houston,Emmanouil Tampakakis,Anita C. Bacher,Parker Rhodes,Stephen C. Mathai,Rachel L. Damico,Todd M. Kolb,Laura K. Hummers,Ami A. Shah,Zsuzsanna H. McMahan,Celia P. Corona-Villalobos,Stefan L. Zimmerman,Fredrick M. Wigley,Paul M. Hassoun,David A. Kass,Ryan J. Tedford +16 more
TL;DR: RV contractile reserve is depressed in SSc-PAH versus IPAH subjects, associated with reduced calcium recycling during exercise, and RV dilation during exercise can predict adverse ventricular-vascular coupling in PAH patients.
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Ambrisentan and Tadalafil Up-front Combination Therapy in Scleroderma-associated Pulmonary Arterial Hypertension
Paul M. Hassoun,Roham T. Zamanian,Rachel L. Damico,Noah Lechtzin,Rubina M. Khair,Todd M. Kolb,Ryan J. Tedford,Olivia L. Hulme,Traci Housten,Chiara Pisanello,Takahiro Sato,Erica H. Pullins,Celia P. Corona-Villalobos,Stefan L. Zimmerman,Mohamed A. Gashouta,Omar A. Minai,Fernando Torres,Reda E. Girgis,Kelly Chin,Stephen C. Mathai +19 more
TL;DR: Up-front combination therapy with ambrisentan and tadalafil significantly improved hemodynamics, RV structure and function, and functional status in treatment-naive patients with SSc-PAH and may represent a very effective therapy for this patient population.
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Prognostic value of the pre-transplant diastolic pulmonary artery pressure–to–pulmonary capillary wedge pressure gradient in cardiac transplant recipients with pulmonary hypertension
Ryan J. Tedford,Claude A. Beaty,Stephen C. Mathai,Todd M. Kolb,Rachel L. Damico,Paul M. Hassoun,Peter J. Leary,David A. Kass,Ashish S. Shah +8 more
TL;DR: This large analysis investigating the prognostic value of DPG found an elevated DPG had no effect on post-transplant survival in patients with PH and an elevated TPG and PVR.
Journal ArticleDOI
Serum Endostatin Is a Genetically Determined Predictor of Survival in Pulmonary Arterial Hypertension
Rachel L. Damico,Todd M. Kolb,Lidenys Valera,Lan Wang,Traci Housten,Ryan J. Tedford,David A. Kass,Nicholas Rafaels,Li Gao,Kathleen C. Barnes,Raymond L. Benza,James L. Rand,Rizwan Hamid,James E. Loyd,Ivan M. Robbins,Anna R. Hemnes,Wendy K. Chung,Eric D. Austin,M. Bradley Drummond,Stephen C. Mathai,Paul M. Hassoun +20 more
TL;DR: Serum ES correlated with poor functional status, decreased exercise tolerance, and invasive hemodynamics variables, and a loss-of-function, missense variant in the gene encoding ES, Col18a1, was linked to lower circulating protein and was independently associated with reduced mortality.