R
Rachel Scheffelaar
Researcher at VU University Amsterdam
Publications - 12
Citations - 1433
Rachel Scheffelaar is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Peptidomimetic & Modular design. The author has an hindex of 9, co-authored 12 publications receiving 1286 citations.
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Journal ArticleDOI
Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity
TL;DR: An overview of general strategies that allow the design of novel multicomponent reactions is presented and the challenges and opportunities for the future are discussed.
Journal ArticleDOI
Mehrkomponentenreaktionen als Weg zu molekularer Komplexität und Diversität
TL;DR: Mehrkomponentenreaktionen haben sich zu sehr populA¤ren Hilfsmitteln, fA¼r die schnelle Erzeugung von Bibliotheken niedermolekularer organischer/nVerbindungen entwickelt as discussed by the authors.
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A Novel Three-Component Reaction toward Dihydrooxazolopyridines
Rachel Scheffelaar,Monica Paravidino,D. Muilwijk,Martin Lutz,Anthony L. Spek,F. J. J. De Kanter,Romano V. A. Orru,Eelco Ruijter +7 more
TL;DR: The efficient combination of two highly variable multicomponent reactions allows the construction of a very broad range of dihydrooxazolopyridines, an unexplored class of bicyclic compounds.
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Diastereoselective Multicomponent Synthesis of Dihydropyridones with an Isocyanide Functionality
Monica Paravidino,Robin S. Bon,Rachel Scheffelaar,Danielle J. Vugts,Anass Znabet,Rob F. Schmitz,F. J. J. De Kanter,Martin Lutz,Anthony L. Spek,Marinus B. Groen,Romano V. A. Orru +10 more
TL;DR: In a search for new multicomponent strategies leading to valuable small heterocycles, a new highly diastereoselective four-component reaction (4CR) was found in which a phosphonate, nitriles, aldehydes, and isocyanoacetates combine to afford functionalized 3-isOCyano-3,4-dihydro-2-pyridones.
Journal ArticleDOI
A Flexible Six-Component Reaction To Access Constrained Depsipeptides Based on a Dihydropyridinone Core
Monica Paravidino,Rachel Scheffelaar,Rob F. Schmitz,Frans J. J. de Kanter,Marinus B. Groen,Eelco Ruijter,Romano V. A. Orru +6 more
TL;DR: Highly functionalized and conformationally constrained depsipeptides based on a dihydropyridin-2-one core are prepared by the combination of a four- and a three-component reaction.