Journal ArticleDOI
Mehrkomponentenreaktionen als Weg zu molekularer Komplexität und Diversität
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TLDR
Mehrkomponentenreaktionen haben sich zu sehr populA¤ren Hilfsmitteln, fA¼r die schnelle Erzeugung von Bibliotheken niedermolekularer organischer/nVerbindungen entwickelt as discussed by the authors.Abstract:
Mehrkomponentenreaktionen haben sich zu sehr populA¤ren Hilfsmitteln\nfA¼r die schnelle Erzeugung von Bibliotheken niedermolekularer organischer\nVerbindungen entwickelt. Um dabei auch genA¼gend molekulare DiversitA¤t\nund KomplexitA¤t sicherzustellen, gibt es einen kontinuierlichen\nBedarf an neuen Reaktionen. Auch wenn der Zufall immer eine wichtige\nRolle in der Entdeckung neuer (Mehrkomponenten-)Reaktionen gespielt\nhat, so ist die Bedeutung gezielter Entwicklungsstrategien im letzten\nJahrzehnt bestA¤ndig gestiegen. Hier prA¤sentieren wir einen allgemeinen\nAœberblick zu Strategien bei der Entwicklung neuer Mehrkomponentenreaktionen.\nDabei werden Herausforderungen und Chancen fA¼r die Zukunft diskutiert.read more
Citations
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Recent Developments in Enantioselective Metal‐Catalyzed Domino Reactions
Hervé Clavier,Hélène Pellissier +1 more
TL;DR: In this article, the major progress in the field of enantioselective one-, two-, and multi-component domino reactions promoted by chiral metal catalysts, covering the literature since the beginning of 2012, is discussed.
Journal ArticleDOI
Robust Atomistic Modeling of Materials, Organometallic, and Biochemical Systems.
Sebastian Spicher,Stefan Grimme +1 more
TL;DR: A generic force field named GFN‐FF is presented, which is completely newly developed to enable fast structure optimizations and molecular‐dynamics simulations for basically any chemical structure consisting of elements up to radon.
Journal ArticleDOI
A Diversity-Oriented Approach to Spiroindolines: Post-Ugi Gold-Catalyzed Diastereoselective Domino Cyclization
Sachin G. Modha,Amit Kumar,Amit Kumar,Dipak D. Vachhani,Jeroen Jacobs,Sunil K. Sharma,Virinder S. Parmar,Luc Van Meervelt,Erik V. Van der Eycken +8 more
TL;DR: A post-Ugi gold-catalyzed domino cyclization method to generate spiroindolines, which was remarkable, as the attack on the a-position of an alkyne conjugated with an amide is rare, and trapping of the spiro intermediate by a sterically hindered tert-butyl amide was rather unexpected, as was the diastereoselectivity observed.
Journal ArticleDOI
Photocascade Catalysis: A New Strategy for Cascade Reactions
TL;DR: This Concept article highlights recent advances in the rapidly developing field of visible-light-driven, single-photocatalyst-promoted photocascade catalysis and its application in the discovery of novel reactivities suitable for cascade reactions.
Journal ArticleDOI
Visible-Light-Driven Aza-ortho-quinone Methide Generation for the Synthesis of Indoles in a Multicomponent Reaction
TL;DR: A visible-light-driven radical-mediated strategy for the in situ generation of aza-ortho-quinone methides from 2-vinyl-substituted anilines and alkyl radical precursors is described, which enables an efficient multicomponent reaction of2-vinylanilines, halides, and sulfur ylides and has a wide substrate scope and good functional group tolerance.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Diego J. Ramón,Miguel Yus +1 more
TL;DR: Asymmetric multicomponent reactions involve the preparation of chiral compounds by the reaction of three or more reagents added simultaneously and has some advantages over classic divergent reaction strategies, such as lower costs, time, and energy, as well as environmentally friendlier aspects.