R
Rafael B. R. León-Cachón
Researcher at University of Monterrey
Publications - 18
Citations - 204
Rafael B. R. León-Cachón is an academic researcher from University of Monterrey. The author has contributed to research in topics: Population & Pharmacogenetics. The author has an hindex of 7, co-authored 18 publications receiving 172 citations. Previous affiliations of Rafael B. R. León-Cachón include Universidad Autónoma de Nuevo León.
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Journal ArticleDOI
Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a Mesoamerican population: Evidence for IRF6 and variants at 8q24 and 10q25
Augusto Rojas-Martinez,Heiko Reutter,Oscar F. Chacon-Camacho,Rafael B. R. León-Cachón,Sergio G. Munoz-Jimenez,Stefanie Nowak,Jessica Becker,Ruth Herberz,Kerstin U. Ludwig,Mario Paredes-Zenteno,Abelardo Arizpe-Cantú,Susanne Raeder,Stefan Herms,Rocio Ortiz-Lopez,Michael Knapp,Per Hoffmann,Markus M. Nöthen,Elisabeth Mangold +17 more
TL;DR: It is suggested that IRF6 and the 10q25 and 8q24 loci confer a risk for the development of NSCL/P in persons of Mayan origin.
Journal ArticleDOI
SeXY chromosomes and the immune system: reflections after a comparative study.
Irene Meester,Edgar Manilla-Muñoz,Rafael B. R. León-Cachón,Gustavo A. Paniagua-Frausto,Diego Carrión-Alvarez,C. Orelli Ruiz-Rodríguez,Ximena Rodríguez-Rangel,Joyce Marie García-Martínez +7 more
TL;DR: The X chromosome is not enriched for ISRG, though particular X-linked genes may be responsible for sex differences in certain immune responses and particular epigenetic controllers were preferentially expressed in leukocytes.
Journal ArticleDOI
A pharmacogenetic pilot study reveals MTHFR , DRD3 , and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers
Rafael B. R. León-Cachón,Rafael B. R. León-Cachón,Jorge A. Ascacio-Martínez,María E. Gamino-Peña,Ricardo M. Cerda-Flores,Irene Meester,Hugo L. Gallardo-Blanco,Magdalena Gómez-Silva,Everardo Piñeyro-Garza,Hugo A. Barrera-Saldaña +9 more
TL;DR: Six gene polymorphisms were found to have a significant effect on ATV pharmacokinetics and the combination of MTHFR, DRD3 and MDR1 polymorphisms associated with a slow ATV metabolizer phenotype.
Journal Article
Individual response to drug therapy: Bases and study approaches
TL;DR: The field of predicting responses to drugs has different strategies and methods, among which the authors find: the use of liver microsomes, cell models, monitoring of probe drugs, assays with recombinant proteins and recently theUse of microarray platforms or DNAchips.
Journal ArticleDOI
Genotypic and Phenotypic Factors Influencing Drug Response in Mexican Patients With Type 2 Diabetes Mellitus.
Hector E. Sanchez-Ibarra,Luisa M. Reyes-Cortes,Xian-Li Jiang,Claudia M. Luna-Aguirre,Dionicio Aguirre-Trevino,Ivan A. Morales-Alvarado,Rafael B. R. León-Cachón,Fernando J. Lavalle-González,Faruck Morcos,Hugo A. Barrera-Saldaña +9 more
TL;DR: The screening of OADs response related genetic and clinical factors could help improve the prescribing and dosing of O ADs for T2DM patients and thus contribute to the design of personalized treatments.