R
Rafael López-Rojas
Researcher at University of Seville
Publications - 34
Citations - 2538
Rafael López-Rojas is an academic researcher from University of Seville. The author has contributed to research in topics: Acinetobacter baumannii & Colistin. The author has an hindex of 20, co-authored 34 publications receiving 2136 citations. Previous affiliations of Rafael López-Rojas include Carlos III Health Institute & Spanish National Research Council.
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Journal ArticleDOI
ARG-ANNOT, a New Bioinformatic Tool To Discover Antibiotic Resistance Genes in Bacterial Genomes
Sushim K. Gupta,Babu Roshan Padmanabhan,Seydina M. Diene,Rafael López-Rojas,Marie Kempf,Luce Landraud,Jean-Marc Rolain +6 more
TL;DR: A concise database for BLAST using a Bio-Edit interface that can detect AR genetic determinants in bacterial genomes and can rapidly and easily discover putative new AR geneticeterminants is created.
Journal ArticleDOI
Role of acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice.
Jennifer A. Gaddy,Brock A. Arivett,Michael J. McConnell,Rafael López-Rojas,Jerónimo Pachón,Luis A. Actis +5 more
TL;DR: It is demonstrated that the virulence of the ATCC 19606T strain depends on the expression of a fully active acinetobactin-mediated system, and Interestingly, the three models also showed that impairment of BasD production results in an intermediate virulence phenotype compared to those of the parental strain and the BauA mutant.
Journal ArticleDOI
Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii
Rafael López-Rojas,Juan Domínguez-Herrera,Michael J. McConnell,Fernando Docobo-Pérez,Younes Smani,María José Fernández-Reyes,Luis Rivas,Jerónimo Pachón +7 more
TL;DR: The colistin-resistant strain has lower affinity for Colistin, reduced in vivo fitness, and decreased virulence, both in terms of mortality and survival in a mouse model of peritoneal sepsis, which may explain the low incidence and dissemination of colistIn resistance in A. baumannii in clinical settings.
Journal ArticleDOI
Vaccination with Outer Membrane Complexes Elicits Rapid Protective Immunity to Multidrug-Resistant Acinetobacter baumannii
Michael J. McConnell,Juan Domínguez-Herrera,Younes Smani,Rafael López-Rojas,Fernando Docobo-Pérez,Jerónimo Pachón +5 more
TL;DR: Results indicate that prophylactic vaccination and antibody-based therapies based on an outer membrane complex vaccine may be viable approaches to preventing the morbidity and mortality caused by A. baumannii.
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Efficacy of Rifampin and Its Combinations with Imipenem, Sulbactam, and Colistin in Experimental Models of Infection Caused by Imipenem-Resistant Acinetobacter baumannii
María Eugenia Pachón-Ibáñez,Fernando Docobo-Pérez,Rafael López-Rojas,Juan Domínguez-Herrera,Manuel E. Jiménez-Mejías,A. García-Curiel,C. Pichardo,Luis Jiménez,Jerónimo Pachón +8 more
TL;DR: Rifampin in monotherapy or with imipenem, sulbactam, or colistin showed efficacy against MDR A. baumannii in experimental models of pneumonia and meningitis.