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Rafael López-Rojas

Researcher at University of Seville

Publications -  34
Citations -  2538

Rafael López-Rojas is an academic researcher from University of Seville. The author has contributed to research in topics: Acinetobacter baumannii & Colistin. The author has an hindex of 20, co-authored 34 publications receiving 2136 citations. Previous affiliations of Rafael López-Rojas include Carlos III Health Institute & Spanish National Research Council.

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Journal ArticleDOI

Comparative activity of a polyhexanide-betaine solution against biofilms produced by multidrug-resistant bacteria belonging to high-risk clones.

Jesús Machuca, +4 more
- 01 Sep 2019 - 
TL;DR: The activity of PHMB-B was superior to that of 2% chlorhexidine in those biofilms of high-risk and/or multidrug-resistant bacterial clones, and the effect of PH MB-B and chlor hexidine on biofilm was evaluated by spectrophotometry and cell viability assays.
Journal ArticleDOI

Sequence-activity relationship, and mechanism of action of mastoparan analogues against extended-drug resistant Acinetobacter baumannii

Xavier Vila-Farrés, +6 more
- 28 Aug 2015 - 
TL;DR: Results suggested that several analogues of mastoparan could be good candidates in the battle against highly resistant A. baumannii infections since they showed good activity and high stability.
Journal ArticleDOI

In vitro activity of a polyhexanide–betaine solution against high-risk clones of multidrug-resistant nosocomial pathogens

Rafael López-Rojas, +3 more
- 01 Jan 2017 - 
TL;DR: Polyhexanide-betaine presented bactericidal activity against all MDR clinical isolates tested, including high-risk clones, at significantly lower concentrations and time of activity than those commercially used.
Journal ArticleDOI

Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System.

Laura Fernandez-Garcia, +10 more
- 26 Apr 2018 - 
TL;DR: A link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 is found.
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Colistin Dosage without Loading Dose Is Efficacious when Treating Carbapenem-Resistant Acinetobacter baumannii Ventilator-Associated Pneumonia Caused by Strains with High Susceptibility to Colistin.

Rocío Álvarez-Marín, +9 more
- 19 Dec 2016 - 
TL;DR: Multidrug-resistant A. baumannii VAP treated with colistin does not have a different mortality compared to lower airways colonization, among patients on mechanical-ventilation, in a setting of high susceptibility to colistIn.