Rafaela Souza

TL;DR: The phytochemical study of Calea uniflora led to the isolation of nine phenolic compounds identified as noreugenin, ethyl caffeate, which did not present cytotoxic effect towards THP-1 cells, and compound 2 was 3.5-fold more selective than the mixture of 3+4.

TL;DR: The isolated chromenes 1 and 3 show a moderate leishmanicidal activity, and the isolated compounds are here reported for the first time in C. pinnatifida.

TL;DR: In this article, a new furanoheliangolide sesquiterpene lactone named 11,13-dihydroxy-calaxin was found to have promising trypanocidal and leishmanicidal activity.

TL;DR: It is demonstrated that C. uniflora exhibits a significant anti‐inflammatory activity via inhibition of the leukocyte influx and degree of exudation, and these effects were associated with a decrease in the levels of several proinflammatory mediators.

TL;DR: In this review, the literature data up to December 2016 is compiled, furnishing a comprehensive survey about medicinal uses, chemistry, and biological activities from Calea species.