Raffaella Bergottini

TL;DR: TIR8 represents a negative pathway of regulation of the IL-1 receptor/TLR system, expressed in epithelial cells and dendritic cells, crucial for tuning inflammation in the gastrointestinal tract.

TL;DR: The results suggest that, during natural aging, collagen accumulation in the lung and its progressive fibrosis are mainly due to a reduced proteolytic activity of MMP, in which TIMP-1 and -2 seem to be the major regulating factors.

TL;DR: Gimatecan was highly effective in delaying disease manifestations in all tumor systems investigated and showed a therapeutic benefit in terms of survival increase, and the good oral availability allowed a prolonged daily treatment regimen, which seems the most promising to exploit the therapeutic potential of the drug.

TL;DR: The present study demonstrated the occurrence of the organism in wild red deer, chamois, and roe deer from the Val Fontana in northern Italy, with a statistically significant negative correlation between CAR bacilli infection and the presence of lymphoid follicles.

TL;DR: In this paper, the authors demonstrated the occurrence of the organism in wild red deer (Cervus elaphus hippelaphus), chamois, and roe deer (Capreolus capreolaus) from the Val Fontana in northern Italy, with a statistically significant negative correlation between CAR bacilli infection and the presence of lymphoid follicles.