E
Emilio Hirsch
Researcher at University of Turin
Publications - 344
Citations - 23598
Emilio Hirsch is an academic researcher from University of Turin. The author has contributed to research in topics: Signal transduction & PI3K/AKT/mTOR pathway. The author has an hindex of 76, co-authored 322 publications receiving 20914 citations. Previous affiliations of Emilio Hirsch include University of São Paulo & University of Eastern Piedmont.
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Journal ArticleDOI
Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
Emilio Hirsch,Vladimir L. Katanaev,Cecilia Garlanda,Ornella Azzolino,Luciano Pirola,Lorenzo Silengo,Silvano Sozzani,Alberto Mantovani,Alberto Mantovani,Fiorella Altruda,Matthias P. Wymann +10 more
TL;DR: Results demonstrate that PI3Kγ is a crucial signaling molecule required for macrophage accumulation in inflammation and shows reduced migration toward a wide range of chemotactic stimuli and a severely defective accumulation in a septic peritonitis model.
Journal ArticleDOI
PI3K/AKT signaling pathway and cancer: an updated review.
TL;DR: The impact of class I catalytic subunit mutations on AKT-mediated cellular processes that control crucial mechanisms in tumor development are elucidated, exploiting the potential benefits of PI3K signaling inhibitors in clinical use.
Journal ArticleDOI
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
Montserrat Camps,Thomas Rückle,Hong Ji,Vittoria Ardissone,Felix Rintelen,Jeffrey P. Shaw,Chiara Ferrandi,Christian Chabert,Corine Gillieron,Bernard Françon,Thierry Martin,Denise Gretener,Dominique Perrin,Didier Leroy,Pierre-Alain Vitte,Emilio Hirsch,Matthias P. Wymann,Rocco Cirillo,Matthias Schwarz,Christian Rommel +19 more
TL;DR: It is shown that Pik3cg−/− mice are largely protected in mouse models of rheumatoid arthritis; this protection correlates with defective neutrophil migration, further validating PI3Kγ as a therapeutic target.
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Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
Cecilia Garlanda,Emilio Hirsch,Silvia Bozza,Antonietta Salustri,Marika De Acetis,Rachele Nota,Alessia Maccagno,Federica Riva,Barbara Bottazzi,Giuseppe Peri,Andrea Doni,Luca Vago,Marina Botto,Rita De Santis,Paolo Carminati,Gregorio Siracusa,Fiorella Altruda,Annunciata Vecchi,Luigina Romani,Alberto Mantovani,Alberto Mantovani +20 more
TL;DR: The long pentraxin Ptx3 is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents, in particular to the opportunistic fungal pathogen Aspergillus fumigatus.
Journal ArticleDOI
Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways
Michael A. Crackower,Gavin Y. Oudit,Ivona Kozieradzki,Ivona Kozieradzki,Renu Sarao,Renu Sarao,Hui Sun,Takehiko Sasaki,Takehiko Sasaki,Emilio Hirsch,Akira Suzuki,Tetsuo Shioi,Junko Irie-Sasaki,Junko Irie-Sasaki,Rajan Sah,Hai-Ying M. Cheng,Hai-Ying M. Cheng,Vitalyi O. Rybin,Giuseppe Lembo,Luigi Fratta,Antonio J. Oliveira-dos-Santos,Jeffery L. Benovic,C. Ronald Kahn,Seigo Izumo,Susan F. Steinberg,Matthias P. Wymann,Peter H. Backx,Josef M. Penninger,Josef M. Penninger +28 more
TL;DR: The data show that PTEN has an important in vivo role in cardiomyocyte hypertrophy and GPCR signaling and identify a function for the PTEN-PI3Kgamma pathway in the modulation of heart muscle contractility.