Raffaella Origa

TL;DR: Although the cause of short stature in children with thalassemia major is not well understood, it is believed to be multifactorial and many different factors including iron overload, intensive use of iron chelators, and gonadal damage may interact.

TL;DR: It is found that KLF1 mutations modulate the phenotype in a cohort of α-thalassemia carriers, and these mutations trigger a series of benign human red blood phenotypes, such as an increase in HbA2 and HBF.

TL;DR: This work has shown that MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance, and that these mutations are most common in patients with myelodysplastic syndromes.

TL;DR: Pinto et al. as discussed by the authors analyzed the outcome of 24 patients with pulmonary arterial hypertension documented by right heart catheterization, and they reported that with a median follow-up of 4 years, 54% died, most of which deaths were attributable to PAH.