J
Jean-Benoît Arlet
Researcher at Paris Descartes University
Publications - 124
Citations - 2247
Jean-Benoît Arlet is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 22, co-authored 85 publications receiving 1726 citations. Previous affiliations of Jean-Benoît Arlet include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
Michael Dussiot,Thiago Trovati Maciel,Aurélie Fricot,Céline Chartier,Olivier Negre,Joel Veiga,Damien Grapton,Etienne Paubelle,Emmanuel Payen,Yves Beuzard,Philippe Leboulch,Jean-Antoine Ribeil,Jean-Benoît Arlet,Francine Côté,Geneviève Courtois,Yelena Ginzburg,Thomas O. Daniel,Rajesh Chopra,Victoria Sung,Olivier Hermine,Ivan C. Moura +20 more
TL;DR: Observations suggest that ActRIIA ligand traps may have therapeutic relevance in β-thalassemia by suppressing the deleterious effects of GDF11, a cytokine which blocks terminal erythroid maturation through an autocrine amplification loop involving oxidative stress and α-globin precipitation.
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Reactive haemophagocytic syndrome in adult-onset Still’s disease: a report of six patients and a review of the literature
TL;DR: RHS is not uncommon in AOSD and should be evoked in a patient with AOSd in the absence of hyperleucocytosis, thrombocytopenia, lymphopenia and coagulopathy, or in the presence of high serum ferritin and triglyceride levels.
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Antineutrophil cytoplasmic antibody-associated vasculitides and IgG4-related disease: A new overlap syndrome
François-Xavier Danlos,Giovanni Maria Rossi,Daniel Engelbert Blockmans,Giacomo Emmi,Andreas Kronbichler,Stéphane Durupt,Claire Maynard,Luminita Luca,Cyril Garrouste,Bertrand Lioger,Rachel Mourot-Cottet,Robin Dhote,Jean-Benoît Arlet,Thomas Hanslik,Philippe Rouvier,Mikael Ebbo,Xavier Puéchal,Dominique Nochy,Agnès Carlotti,Luc Mouthon,Loïc Guillevin,Augusto Vaglio,Benjamin Terrier +22 more
TL;DR: Clinicians should consider that atypical manifestations during AAV could be related to IgG4-RD rather than to refractory granulomatous or vasculitic lesions, as both diseases may overlap.
Journal ArticleDOI
Pulmonary fibrosis in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: a series of 49 patients and review of the literature.
Cloé Comarmond,Bruno Crestani,Abdellatif Tazi,Baptiste Hervier,Sylvain Adam-Marchand,Hilario Nunes,Fleur Cohen-Aubart,Marie Wislez,Jacques Cadranel,Bruno Housset,Célia Lloret-Linares,Pascal Sève,Christian Pagnoux,Sébastien Abad,Juliette Camuset,Boris Bienvenu,Michael Duruisseaux,Eric Hachulla,Jean-Benoît Arlet,Mohammed Hamidou,Alfred Mahr,Matthieu Resche-Rigon,Anne-Laure Brun,Philippe Grenier,Patrice Cacoub,David Saadoun +25 more
TL;DR: PF is a rare manifestation of AAV with a very poor prognosis and 3-year survival rate in patients treated with glucocorticoids alone or combined with an immunosuppressant (CYC or RTX) as induction therapy was 64% and 94% respectively.
Journal ArticleDOI
HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia
Jean-Benoît Arlet,Jean-Antoine Ribeil,Flavia Guillem,Olivier Negre,Adonis Hazoumé,Guillaume Marcion,Yves Beuzard,Michael Dussiot,Ivan Moura,Samuel Demarest,Isaure Chauvot de Beauchêne,Zakia Belaid-Choucair,Margaux Sevin,Thiago Trovati Maciel,Christian Auclair,Philippe Leboulch,Stany Chretien,Luba Tchertanov,Véronique Baudin-Creuza,Renaud Seigneuric,Michaela Fontenay,Carmen Garrido,Olivier Hermine,Geneviève Courtois +23 more
TL;DR: In vitro, in vitro, it is shown in vitro that during the maturation of human β-TM erythroblasts, HSP70 interacts directly with free α-globin chains, resulting in end-stage maturation arrest and apoptosis.