Raj D. Mehra

TL;DR: The distribution pattern and levels of expression of two estrogen receptor (ER) subtypes, ERα and ERβ, in the normal adult and aged female rat hippocampus are studied with the objective to establish baseline data and the changes that occur during aging.

TL;DR: Modulation of the antiapoptotic (Bcl-2) and proapoptosis (Bax) proteins in the hippocampus of both the ovariectomized (OVX) rats as well as those given E2 or TAM subcutaneously as a daily dose for four weeks post-ovariectomy are reported.

TL;DR: Long-term estrogen therapy modulates the synaptic plasticity of hippocampal neurons and presumably, the agonist biocharacter of TAM as observed in the present investigations, may in the long run have a potential in the treatment and prevention of various estrogen-related disorders.

TL;DR: Faulty migration, delayed maturation and alteration in nuclear area measurements of Purkinje cells subsequent to arsenic exposure provided morphological evidence of structural alterations subsequent to arsenite induced developmental neurotoxicity which could be presumed to be the underlying basis for some of the functional deficits encountered in the later period of life.

TL;DR: It is concluded that the effectiveness of regular and moderate intensity physical exercise is age-dependent while the action of E2 treatment is comparable between the ageing and old female rats on maintaining cognition and its underlying molecular mechanisms.