R
Ralf Küppers
Researcher at University of Duisburg-Essen
Publications - 306
Citations - 27068
Ralf Küppers is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Germinal center & Lymphoma. The author has an hindex of 77, co-authored 283 publications receiving 24677 citations. Previous affiliations of Ralf Küppers include University of Cologne & Columbia University.
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Viral mimic for B-cell survival
TL;DR: This issue of Blood shows that the Epstein-Barr virus–encoded latent membrane protein 2A (LMP2A) is able to replace the BCR survival signal in BCR-deficient human germinal center.
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Genomic imbalances in Hodgkin lymphoma
TL;DR: In this issue of Blood, Steidl and colleagues present exciting novel insights into pathogenesis and clinical behavior of classical Hodgkin lymphoma by performing array comparative genomic hybridization studies to detect genomic gains and losses.
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Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter’s Trans-Formed DLBCL and Germinal Center B-Cells
Barbara Uhl,Katharina T. Prochazka,Katrin Pansy,Kerstin Wenzl,J. Strobl,Claudia Baumgartner,M. Szmyra,James Elvis Waha,Axel Wolf,Peter Valentin Tomazic,Elisabeth Steinbauer,Maria Steinwender,Sabine Friedl,Marc A. Weniger,Ralf Küppers,Martin Pichler,Hildegard T. Greinix,Georg Stary,Alan G. Ramsay,Benedetta Apollonio,Julia Feichtinger,Christine Beham-Schmid,Peter Neumeister,Alexander Deutsch +23 more
TL;DR: The data indicate that the chemokine receptor expression profile of RS differs substantially from that of de novo DLBCL and tFL, and these multiple dysregulated chemokin receptors could represent novel clinical markers as diagnostic and prognostic tools.
Reed-Sternberg cells of Hodgkin lymphoma specific gene expression program in Hodgkin and - Loss of the B-lineage
Martin-Leo Hansmann,Riccardo Dalla-Favera,Klaus Rajewsky,Ralf Küppers,Ines Schwering,Andreas Bräuninger,Ulf Klein,Berit Jungnickel,Marianne Tinguely,Volker Diehl +9 more
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The Biology of Ocular Adnexal Marginal Zone Lymphomas
TL;DR: The role of antigenic stimulation in the pathogenesis of OAMZL is supported by the detection of somatic mutations in their rearranged immunoglobulin V genes, and their derivation from germinal-center-experienced B cells, by a restricted IGHV gene usage, and the validation of autoreactivity of the antibodies in selected cases.