R
Ralf Küppers
Researcher at University of Duisburg-Essen
Publications - 306
Citations - 27068
Ralf Küppers is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Germinal center & Lymphoma. The author has an hindex of 77, co-authored 283 publications receiving 24677 citations. Previous affiliations of Ralf Küppers include University of Cologne & Columbia University.
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Journal ArticleDOI
Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions
Marc Seifert,Martina Przekopowitz,Sarah Taudien,Anna Lollies,Viola Ronge,Britta Drees,Monika Lindemann,Uwe Hillen,Harald Engler,Bernhard B. Singer,Ralf Küppers +10 more
TL;DR: Memory B-cell characteristics of human IgM+IgD+CD27+ B cells are substantiated in that they share typical memory B- cell transcription patterns with IgG+ post-GC B cells and show a faster and more vigorous restimulation potential, a hallmark of immune memory.
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Pathogenesis of classical and lymphocyte-predominant Hodgkin lymphoma.
TL;DR: Hodgkin and Reed-Sternberg cells in classical Hodgkin lymphoma and lymphocytic and histiocytic cells in nodular lymphocyte-predominant HL and in NLPHL have largely lost their B cell phenotype and aberrantly express markers and transcriptional regulators of other hematolymphoid cell types.
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Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation
Marc Seifert,Ralf Küppers +1 more
TL;DR: It is revealed that a highly diverse and often very large population of memory B cells is generated from a given GC B cell clone, and that (preferentially IgM)memory B cells are generated already early in the GC reaction.
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Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient
Holger Kanzler,Martin-Leo Hansmann,Ursula Kapp,Jürgen Wolf,Volker Diehl,Klaus Rajewsky,Ralf Küppers +6 more
TL;DR: L1236 is the first cell line established from a case of HD for which a derivation from the H- RS cells of the patient could be demonstrated and the selective isolation of identical V gene rearrangements from multiple single H-RS cells demonstrates that these cells represented a clonal population in the patient.
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Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life.
TL;DR: In the human like in the mouse, and independently of age, somatically mutated memory B cells accumulate in the compartment of IgM−IgD− cells, whereas the IgM+Ig D+ subpopulation consists of cells whose antibody repertoire is mainly determined by V region gene rearrangements and N‐region insertion, at the molecular level.