R
Ralph A. Gruppo
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 71
Citations - 4134
Ralph A. Gruppo is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Haemophilia A & Haemophilia. The author has an hindex of 28, co-authored 71 publications receiving 3925 citations. Previous affiliations of Ralph A. Gruppo include Wake Forest University & Boston Children's Hospital.
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Journal ArticleDOI
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
Gallia Levy,William C. Nichols,Eric C.-Y. Lian,Tatiana Foroud,Jeanette N. McClintick,Beth McGee,Angela Y. Yang,David R. Siemieniak,Kenneth R. Stark,Ralph A. Gruppo,Ravindra Sarode,Susan B. Shurin,Visalam Chandrasekaran,Sally P. Stabler,Hernan Sabio,Eric E. Bouhassira,Jefferson D. Upshaw,David Ginsburg,Han-Mou Tsai +18 more
TL;DR: In this article, the ADAMTS family of zinc metalloproteinase genes (ADAMTS13) was identified as the molecular mechanism responsible for TTP, and it was shown that the deficiency of ADADTS13 is the molecular mechanisms responsible for the development of TTP.
Journal ArticleDOI
Low-dose tissue plasminogen activator thrombolysis in children
Michael Wang,Taru Hays,Vinod Balasa,Rochelle Bagatell,Ralph A. Gruppo,Eric F. Grabowski,Leonard A. Valentino,George Tsao-Wu,Marilyn J. Manco-Johnson +8 more
TL;DR: TPA in very low doses appears to be safe and effective for thrombolysis of acute thromboses in most children, given appropriate patient selection.
Journal ArticleDOI
Clinical evaluation of an advanced category antihaemophilic factor prepared using a plasma/albumin-free method: pharmacokinetics, efficacy, and safety in previously treated patients with haemophilia A
Michael D. Tarantino,Peter William Collins,C. R. M. Hay,Amy D. Shapiro,Ralph A. Gruppo,Erik Berntorp,G. Bray,S. A. Tonetta,Phillip Schroth,Anastassios D. Retzios,S. S. Rogy,M Sensel,Bruce M. Ewenstein +12 more
TL;DR: It is suggested that rAHF‐PFM is efficacious and safe, without increased immunogenicity, for the treatment of haemophilia A, and bioequivalence, based on area under the plasma concentration vs. time curve and adjusted in vivo recovery, is demonstrated.
Journal ArticleDOI
The relationship of mutations in the MTHFR, prothrombin, and PAI-1 genes to plasma levels of homocysteine, prothrombin, and PAI-1 in children and adults.
TL;DR: Studies of the incidence of the MTHFR, prothrombin, and PAI-1 4G/5G genotypes in children with thrombosis, when compared to these healthy normals, will provide evidence as to which of these genes are associated withThrombophilia.
Journal ArticleDOI
The plasminogen activator inhibitor-1 gene, hypofibrinolysis, and osteonecrosis.
Charles J. Glueck,Robert N. Fontaine,Ralph A. Gruppo,Davis Stroop,Luann Sieve-Smith,Trent Tracy,Ping Wang +6 more
TL;DR: Heritable hypofibrinolysis conferred by the 4G/4G mutation of the plasminogen activator inhibitor-1 gene seems to be a major pathoetiology of primary osteonecrosis.