R
Ralph A. Tripp
Researcher at University of Georgia
Publications - 320
Citations - 19746
Ralph A. Tripp is an academic researcher from University of Georgia. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 67, co-authored 300 publications receiving 18183 citations. Previous affiliations of Ralph A. Tripp include University of Tennessee & Government of the United States of America.
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Journal ArticleDOI
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.
Evelyn A. Kurt-Jones,Lana Popova,Laura Kwinn,Lia M. Haynes,Les P. Jones,Ralph A. Tripp,Edward E. Walsh,Mason W. Freeman,Douglas T. Golenbock,Larry J. Anderson,Robert W. Finberg,Robert W. Finberg +11 more
TL;DR: A common receptor activation pathway can initiate innate immune responses to both bacterial and viral pathogens.
Journal ArticleDOI
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.
Kazuya Shimoda,Jan van Deursent,Mark Y. Sangster,S R Sarawar,Richard T. Carson,Ralph A. Tripp,Charles C. Chu,Frederick W. Quelle,Tetsuya Nosaka,Dario A. A. Vignali,Peter C. Doherty,Gerard Grosveld,William E. Paul,James N. Ihle +13 more
TL;DR: Stat6-l- mice were deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, and immunoglobulin class switching to IgE, indicating the lack of a non-redundant function in normal development.
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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
William E. Thierfelder,J. M. Van Deursen,K. Yamamoto,Ralph A. Tripp,S. R. Sarawar,R. T. Carson,Mark Y. Sangster,Dario A. A. Vignali,Peter C. Doherty,G. C. Grosveld,James N. Ihle +10 more
TL;DR: All IL-12 functions tested were disrupted, including the induction of IFN-γ, mitogenesis, enhancement of natural killer cytolytic function and Thl differentiation.
Journal ArticleDOI
Defective Lymphoid Development in Mice Lacking Jak3
Tetsuya Nosaka,Jan M. van Deursen,Ralph A. Tripp,William E. Thierfelder,Bruce A. Witthuhn,Anthony McMickle,Peter C. Doherty,Gerard Grosveld,James N. Ihle +8 more
TL;DR: Jak3 plays a critical role in γc signaling and lymphoid development in thymocytes and severe B cell and T cell lymphopenia similar to severe combined immunodeficiency disease (SCID).
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Rapid and sensitive detection of respiratory virus molecular signatures using a silver nanorod array SERS substrate.
Saratchandra Shanmukh,Les P. Jones,Jeremy D. Driskell,Yiping Zhao,Richard A. Dluhy,Ralph A. Tripp +5 more
TL;DR: This novel SERS assay can detect spectral differences between viruses, viral strains, and viruses with gene deletions in biological media and provides rapid diagnostics for detection and characterization of viruses generating reproducible spectra without viral manipulation.