D
Dario A. A. Vignali
Researcher at University of Pittsburgh
Publications - 255
Citations - 37436
Dario A. A. Vignali is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 74, co-authored 219 publications receiving 31388 citations. Previous affiliations of Dario A. A. Vignali include Harvard University & Boston Children's Hospital.
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Journal ArticleDOI
How regulatory T cells work.
TL;DR: The hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate TReg-cell function is proposed.
Journal ArticleDOI
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
Lauren W. Collison,Creg J. Workman,Timothy T. Kuo,Kelli L. Boyd,Yao Wang,Kate M. Vignali,Richard L. Cross,David Sehy,Richard S. Blumberg,Dario A. A. Vignali +9 more
TL;DR: IL-35 is identified as a novel inhibitory cytokine that may be specifically produced by Treg cells and is required for maximal suppressive activity.
Journal ArticleDOI
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Shawn D. Blackburn,Haina Shin,W. Nicholas Haining,W. Nicholas Haining,Tao Zou,Creg J. Workman,Antonio Polley,Michael R. Betts,Gordon J. Freeman,Dario A. A. Vignali,E. John Wherry +10 more
TL;DR: It is shown that exhausted CD8+ T cells are subject to complex layers of negative regulation resulting from the coexpression of multiple inhibitory receptors, and regulation of T cell exhaustion by various inhibitory pathways was nonredundant.
Journal ArticleDOI
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.
Kazuya Shimoda,Jan van Deursent,Mark Y. Sangster,S R Sarawar,Richard T. Carson,Ralph A. Tripp,Charles C. Chu,Frederick W. Quelle,Tetsuya Nosaka,Dario A. A. Vignali,Peter C. Doherty,Gerard Grosveld,William E. Paul,James N. Ihle +13 more
TL;DR: Stat6-l- mice were deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, and immunoglobulin class switching to IgE, indicating the lack of a non-redundant function in normal development.
Journal ArticleDOI
Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
Seng Ryong Woo,Meghan E. Turnis,Monica V. Goldberg,Jaishree Bankoti,Mark J. Selby,Christopher J. Nirschl,Matthew L. Bettini,David M. Gravano,Peter Vogel,Chih Long Liu,Stephanie Tangsombatvisit,Joseph F. Grosso,George J. Netto,Matthew P. Smeltzer,Alcides Chaux,Paul J. Utz,Creg J. Workman,Drew M. Pardoll,Alan J. Korman,Charles G. Drake,Dario A. A. Vignali +20 more
TL;DR: A strong synergy between the PD-1 and LAG-3 inhibitory pathways in tolerance to both self and tumor antigens is defined and it is argued strongly that dual blockade of these molecules represents a promising combinatorial strategy for cancer.