R
Ralph H. Schaloske
Researcher at University of California, San Diego
Publications - 5
Citations - 912
Ralph H. Schaloske is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Stimulation & Dictyostelium discoideum. The author has an hindex of 5, co-authored 5 publications receiving 877 citations.
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Journal ArticleDOI
The phospholipase A2 superfamily and its group numbering system
TL;DR: The PLA(2) superfamily has grown continuously and over the intervening years has required several updates of this Group numbering system, so a number of new PLA( 2)s have been discovered and are now included in this update.
Journal ArticleDOI
Ca2+ regulation in the absence of the iplA gene product in Dictyostelium discoideum.
Ralph H. Schaloske,Daniel F Lusche,Karen Bezares-Roder,Kathrin Happle,Dieter Malchow,Christina Schlatterer +5 more
TL;DR: The view that [Ca2+]i-transients are essential for chemotaxis and differentiation is supported.
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Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages.
TL;DR: It is suggested that an accessory regulatory protein affecting the release of AA must be responsible and the dependency of the LPS/PAF-induced PGE2 production on gene expression can be attributed to the production of cyclooxygenase-2.
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PGE2 release is independent of upregulation of Group V phospholipase A2 during long-term stimulation of P388D1 cells with LPS.
TL;DR: The results suggest that the upregulation of GV PLA2 during long-term LPS stimulation is not required for PGE2 production by P388D1 cells, and pyrrophenone and second generation antisense oligonucleotides designed to specifically inhibit expression and activity of GVs PLA2 are utilized.
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Arachidonic acid is a chemoattractant for Dictyostelium discoideum cells.
TL;DR: It is reported that arachidonic acid is a chemoattractant for D. discoideum cells differentiated for 8–9 h and motility towards a glass capillary filled with an AA solution was dose-dependent and qualitatively comparable to cAMP-induced chemotaxis.