R
Rama Pati Tripathi
Researcher at Central Drug Research Institute
Publications - 80
Citations - 1930
Rama Pati Tripathi is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Glycosyl & Ascorbic acid. The author has an hindex of 24, co-authored 79 publications receiving 1719 citations. Previous affiliations of Rama Pati Tripathi include Academy of Scientific and Innovative Research.
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Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials.
Mridul Misra,Swaroop Kumar Pandey,Vivek Parashar Pandey,Jyoti Pandey,Renu Tripathi,Rama Pati Tripathi +5 more
TL;DR: A highly atom economic one pot synthesis of tetrahydropyridines was achieved by L-proline/TFA catalysed multicomponent reaction of beta-keto-esters, aromatic aldehydes and anilines.
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NAD+-dependent DNA Ligase (Rv3014c) from Mycobacterium tuberculosis CRYSTAL STRUCTURE OF THE ADENYLATION DOMAIN AND IDENTIFICATION OF NOVEL INHIBITORS
TL;DR: The crystal structure of the adenylation domain of the Mycobacterium tuberculosis NAD+-dependent ligase with bound AMP is reported, which can be used as the basis for rational design of novel antibacterial agents.
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Evaluation of Mycobacterium smegmatis as a possible surrogate screen for selecting molecules active against multi-drug resistant Mycobacterium tuberculosis
TL;DR: The utility of M. smegmatis as a primary screen to shortlist compounds for advanced screening against MDR M. tuberculosis is highlighted and the potential of a screen based on a 'fast grower' mycobacterium to shortlisted compounds which could be active against M DR M.culosis is evaluated.
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Preparation and reactions of sugar azides with alkynes: synthesis of sugar triazoles as antitubercular agents.
Biswajit K. Singh,Amit Kumar Yadav,Brijesh Kumar,Anil N. Gaikwad,Sudhir Sinha,Vinita Chaturvedi,Rama Pati Tripathi +6 more
TL;DR: The synthesized sugar triazoles were evaluated for their antitubercular activity against Mycobacterium tuberculosis H37Rv, where one of the compounds displayed mild antitubcular activity in vitro with MIC 12.5 microg/mL.
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Carbohydrate based potential chemotherapeutic agents: recent developments and their scope in future drug discovery.
TL;DR: This review highlights an overview of development of carbohydrate-based molecules from others and the authors' lab which have shown promising biological activity against front line diseases.