R
Rami Sukarieh
Researcher at McGill University
Publications - 10
Citations - 1317
Rami Sukarieh is an academic researcher from McGill University. The author has contributed to research in topics: EIF4E & Eukaryotic initiation factor. The author has an hindex of 9, co-authored 10 publications receiving 1227 citations.
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Journal ArticleDOI
Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms
TL;DR: It is shown that extracts lacking PABP exhibit dramatically reduced rates of translation, reduced efficiency of 48S and 80S ribosome initiation complex formation, and impaired interaction of eIF4E with the mRNA cap structure.
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Inhibition of Ribosome Recruitment Induces Stress Granule Formation Independently of Eukaryotic Initiation Factor 2α Phosphorylation
Rachid Mazroui,Rami Sukarieh,Marie Eve Bordeleau,Randal J. Kaufman,Randal J. Kaufman,Peter T. Northcote,Junichi Tanaka,Imed E Gallouzi,Jerry Pelletier +8 more
TL;DR: It is demonstrated that interfering with eIF4A activity, an RNA helicase required for the ribosome recruitment phase of translation initiation, induces SG formation and that this event is not dependent on eIF2alpha phosphorylation.
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Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol.
Regina Cencic,Marilyn Carrier,Gabriela Galicia-Vázquez,Marie Eve Bordeleau,Rami Sukarieh,Annie Bourdeau,Brigitte Brem,Jose G. Teodoro,Harald Greger,Michel L. Tremblay,John A. Porco,Jerry Pelletier +11 more
TL;DR: In this article, the authors presented the results of the Canadian Institutes of Health Research (CIHR) Training Grant and the US Lymphoma Foundation Training Grant (USLGF).
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Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs.
Liwei Rong,Mark Livingstone,Rami Sukarieh,Emmanuel Petroulakis,Anne-Claude Gingras,Katherine Crosby,Bradley L. Smith,Roberto D. Polakiewicz,Jerry Pelletier,Maria Ferraiuolo,Nahum Sonenberg +10 more
TL;DR: 4E-BP1 is shown to be a regulator of eIF4E cellular localization in mouse embryo fibroblasts subjected to serum starvation and/or rapamycin treatment, and is also present in the nucleus, where it is thought to stimulate nuclear-cytoplasmic transport of certain mRNAs.
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The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling.
TL;DR: The results indicate that sertraline exerts antiproliferative activity by targeting the mTOR signaling pathway in a REDD1-dependent manner.