R
Regina Cencic
Researcher at McGill University
Publications - 63
Citations - 2923
Regina Cencic is an academic researcher from McGill University. The author has contributed to research in topics: Eukaryotic translation & Eukaryotic initiation factor. The author has an hindex of 27, co-authored 62 publications receiving 2501 citations. Previous affiliations of Regina Cencic include University of Vienna & Boston University.
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Journal ArticleDOI
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol.
Regina Cencic,Marilyn Carrier,Gabriela Galicia-Vázquez,Marie Eve Bordeleau,Rami Sukarieh,Annie Bourdeau,Brigitte Brem,Jose G. Teodoro,Harald Greger,Michel L. Tremblay,John A. Porco,Jerry Pelletier +11 more
TL;DR: In this article, the authors presented the results of the Canadian Institutes of Health Research (CIHR) Training Grant and the US Lymphoma Foundation Training Grant (USLGF).
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Structural conservation of druggable hot spots in protein–protein interfaces
Dima Kozakov,David R. Hall,Gwo-Yu Chuang,Regina Cencic,Ryan Brenke,Laurie E. Grove,Dmitri Beglov,Jerry Pelletier,Adrian Whitty,Sandor Vajda +9 more
TL;DR: The structural and physicochemical signature of druggable sites at PPI interfaces is sufficiently robust to be detectable from the structure of the unliganded protein, even when substantial conformational adaptation is required for optimal ligand binding.
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Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F
Regina Cencic,David R. Hall,Francis Robert,Yuhong Du,Jaeki Min,Lian Li,Min Qui,Iestyn Lewis,Serdar Kurtkaya,Raymond Dingledine,Haian Fu,Dima Kozakov,Sandor Vajda,Jerry Pelletier +13 more
TL;DR: An ultra-high-throughput screen to identify inhibitors that prevent assembly of the eIF4F complex is undertaken and this compound can reverse tumor chemoresistance in a genetically engineered lymphoma mouse model by sensitizing cells to the proapoptotic action of DNA damage.
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c-Myc and eIF4F Are Components of a Feedforward Loop that Links Transcription and Translation
TL;DR: The results suggest the presence of a feedforward loop involving c-Myc and eIF4F that serves to link transcription and translation and that could contribute to the effects of c- myc on cell proliferation and neoplastic growth.
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Repurposing CRISPR/Cas9 for in situ functional assays
Abba Malina,John R. Mills,Regina Cencic,Yifei Yan,James Fraser,Laura M Schippers,Marilène Paquet,Josée Dostie,Jerry Pelletier +8 more
TL;DR: The results establish Cas9 genome editing as a powerful and practical approach for positive in situ genetic screens for targeted gene disruption positive selection assays.