R
Ran-Ran Zhang
Researcher at Yokohama City University
Publications - 19
Citations - 2687
Ran-Ran Zhang is an academic researcher from Yokohama City University. The author has contributed to research in topics: Induced pluripotent stem cell & Transplantation. The author has an hindex of 11, co-authored 19 publications receiving 2043 citations. Previous affiliations of Ran-Ran Zhang include Cincinnati Children's Hospital Medical Center.
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Journal ArticleDOI
Vascularized and functional human liver from an iPSC-derived organ bud transplant
Takanori Takebe,Keisuke Sekine,Masahiro Enomura,Hiroyuki Koike,Masaki Kimura,Takunori Ogaeri,Ran-Ran Zhang,Yasuharu Ueno,Yun-Wen Zheng,Naoto Koike,Shinsuke Aoyama,Yasuhisa Adachi,Hideki Taniguchi +12 more
TL;DR: This is the first report demonstrating the generation of a functional human organ from pluripotent stem cells by transplantation of liver buds created in vitro (iPSC-LBs), and provides a promising new approach to study regenerative medicine.
Journal ArticleDOI
Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant
Takanori Takebe,Ran-Ran Zhang,Hiroyuki Koike,Masaki Kimura,Emi Yoshizawa,Masahiro Enomura,Naoto Koike,Keisuke Sekine,Hideki Taniguchi +8 more
TL;DR: A protocol for the in vitro generation of a 3D liver bud from human iPSC cultures and the monitoring of further hepatic maturation after transplantation at various ectopic sites is described.
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Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids
Rie Ouchi,Shodai Togo,Masaki Kimura,Tadahiro Shinozawa,Masaru Koido,Hiroyuki Koike,Wendy Thompson,Rebekah Karns,Christopher N. Mayhew,Patrick S. McGrath,Heather A. McCauley,Ran-Ran Zhang,Kyle Lewis,Shoyo Hakozaki,Autumn Ferguson,Norikazu Saiki,Yosuke Yoneyama,Ichiro Takeuchi,Yo Mabuchi,Chihiro Akazawa,Hiroshi Yoshikawa,James M. Wells,Takanori Takebe +22 more
TL;DR: A reproducible method is developed to derive multi-cellular human liver organoids composed of hepatocyte-, stellate-, and Kupffer-like cells that exhibit transcriptomic resemblance to in vivo-derived tissues that offer a new approach for studying a personalized basis for inflammation and fibrosis in humans.
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High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell–Derived Organoids
Tadahiro Shinozawa,Masaki Kimura,Yuqi Cai,Norikazu Saiki,Yosuke Yoneyama,Rie Ouchi,Hiroyuki Koike,Mari Maezawa,Ran-Ran Zhang,Andrew Dunn,Autumn Ferguson,Shodai Togo,Kyle Lewis,Wendy Thompson,Akihiro Asai,Takanori Takebe +15 more
TL;DR: Liver organoid-based Toxicity screen (LoT) is a potential assay system for liver toxicology studies, facilitating compound optimization, mechanistic study, and precision medicine as well as drug screening applications.
Journal ArticleDOI
Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells.
Yunzhong Nie,Yun-Wen Zheng,Yun-Wen Zheng,Yun-Wen Zheng,Kei Miyakawa,Soichiro Murata,Ran-Ran Zhang,Keisuke Sekine,Yasuharu Ueno,Takanori Takebe,Takaji Wakita,Akihide Ryo,Hideki Taniguchi +12 more
TL;DR: It is demonstrated that HBV infection in hiPSC-LOs could recapitulate virus life cycle and virus induced hepatic dysfunction, suggesting that hiPSCs may provide a promising individualized infection model for the development of individualized treatment for hepatitis.