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Masaki Kimura
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 24
Citations - 3308
Masaki Kimura is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Induced pluripotent stem cell & Transplantation. The author has an hindex of 11, co-authored 21 publications receiving 2445 citations. Previous affiliations of Masaki Kimura include Yokohama City University.
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Journal ArticleDOI
Vascularized and functional human liver from an iPSC-derived organ bud transplant
Takanori Takebe,Keisuke Sekine,Masahiro Enomura,Hiroyuki Koike,Masaki Kimura,Takunori Ogaeri,Ran-Ran Zhang,Yasuharu Ueno,Yun-Wen Zheng,Naoto Koike,Shinsuke Aoyama,Yasuhisa Adachi,Hideki Taniguchi +12 more
TL;DR: This is the first report demonstrating the generation of a functional human organ from pluripotent stem cells by transplantation of liver buds created in vitro (iPSC-LBs), and provides a promising new approach to study regenerative medicine.
Journal ArticleDOI
Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation
Takanori Takebe,Masahiro Enomura,Emi Yoshizawa,Masaki Kimura,Hiroyuki Koike,Yasuharu Ueno,Takahisa Matsuzaki,Takashi Yamazaki,Takafumi Toyohara,Kenji Osafune,Hiromitsu Nakauchi,Hiroshi Yoshikawa,Hideki Taniguchi +12 more
TL;DR: A generalized method for organ bud formation from diverse tissues by combining pluripotent stem cell-derived tissue-specific progenitors or relevant tissue samples with endothelial cells and mesenchymal stem cells (MSCs).
Journal ArticleDOI
Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant
Takanori Takebe,Ran-Ran Zhang,Hiroyuki Koike,Masaki Kimura,Emi Yoshizawa,Masahiro Enomura,Naoto Koike,Keisuke Sekine,Hideki Taniguchi +8 more
TL;DR: A protocol for the in vitro generation of a 3D liver bud from human iPSC cultures and the monitoring of further hepatic maturation after transplantation at various ectopic sites is described.
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Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids
Rie Ouchi,Shodai Togo,Masaki Kimura,Tadahiro Shinozawa,Masaru Koido,Hiroyuki Koike,Wendy Thompson,Rebekah Karns,Christopher N. Mayhew,Patrick S. McGrath,Heather A. McCauley,Ran-Ran Zhang,Kyle Lewis,Shoyo Hakozaki,Autumn Ferguson,Norikazu Saiki,Yosuke Yoneyama,Ichiro Takeuchi,Yo Mabuchi,Chihiro Akazawa,Hiroshi Yoshikawa,James M. Wells,Takanori Takebe +22 more
TL;DR: A reproducible method is developed to derive multi-cellular human liver organoids composed of hepatocyte-, stellate-, and Kupffer-like cells that exhibit transcriptomic resemblance to in vivo-derived tissues that offer a new approach for studying a personalized basis for inflammation and fibrosis in humans.
Journal ArticleDOI
Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells
Takanori Takebe,Keisuke Sekine,Masaki Kimura,Emi Yoshizawa,Satoru Ayano,Masaru Koido,Shizuka Funayama,Noriko Nakanishi,Tomoko Hisai,Tatsuya Kobayashi,Toshiharu Kasai,Rina Kitada,Akira Mori,Hiroaki Ayabe,Yoko Ejiri,Naoki Amimoto,Yosuke Yamazaki,Shimpei Ogawa,Momotaro Ishikawa,Yasujiro Kiyota,Yasuhiko Sato,Kohei Nozawa,Satoshi Okamoto,Yasuharu Ueno,Hideki Taniguchi +24 more
TL;DR: Vascularized and functional liver tissues generated entirely from iPSCs significantly improved subsequent hepatic functionalization potentiated by stage-matched developmental progenitor interactions, enabling functional rescue against acute liver failure via transplantation.