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Yun-Wen Zheng
Researcher at University of Tsukuba
Publications - 81
Citations - 4085
Yun-Wen Zheng is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Stem cell & Transplantation. The author has an hindex of 22, co-authored 73 publications receiving 3409 citations. Previous affiliations of Yun-Wen Zheng include Yokohama City University & Jiangsu University.
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Journal ArticleDOI
Vascularized and functional human liver from an iPSC-derived organ bud transplant
Takanori Takebe,Keisuke Sekine,Masahiro Enomura,Hiroyuki Koike,Masaki Kimura,Takunori Ogaeri,Ran-Ran Zhang,Yasuharu Ueno,Yun-Wen Zheng,Naoto Koike,Shinsuke Aoyama,Yasuhisa Adachi,Hideki Taniguchi +12 more
TL;DR: This is the first report demonstrating the generation of a functional human organ from pluripotent stem cells by transplantation of liver buds created in vitro (iPSC-LBs), and provides a promising new approach to study regenerative medicine.
Journal ArticleDOI
Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.
Tetsuhiro Chiba,Kaoru Kita,Yun-Wen Zheng,Osamu Yokosuka,Hiromitsu Saisho,Atsushi Iwama,Hiromitsu Nakauchi,Hideki Taniguchi,Hideki Taniguchi +8 more
TL;DR: It is proposed that a minority population, detected as SP cells in HCC cells, possess extreme tumorigenic potential and provide heterogeneity to the cancer stem cell system characterized by distinct hierarchy.
Journal ArticleDOI
Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.
Tetsuhiro Chiba,Yun-Wen Zheng,Kaoru Kita,Osamu Yokosuka,Hiromitsu Saisho,Masafumi Onodera,Hiroyuki Miyoshi,Masayuki Nakano,Yoh Zen,Yasuni Nakanuma,Hiromitsu Nakauchi,Atsushi Iwama,Hideki Taniguchi,Hideki Taniguchi +13 more
TL;DR: In this paper, the authors investigated the role of Bmi1 and β-catenin in hepatic stem/progenitor cell self-renewal in hepatocellular and cholangiocarcinoma.
BASIC-LIVER, PANCREAS, AND BILIARY TRACT Enhanced Self-Renewal Capability in Hepatic Stem/Progenitor Cells Drives Cancer Initiation
Tetsuhiro Chiba,Yun-Wen Zheng,Kaoru Kita,Osamu Yokosuka,Hiromitsu Saisho,Masafumi Onodera,Hiroyuki Miyoshi,Masayuki Nakano,Yoh Zen,Yasuni Nakanuma,Hiromitsu Nakauchi,Atsushi Iwama,Hideki Taniguchi +12 more
TL;DR: Observations imply that the dysregulated self-renewal of hepatic stem/progenitor cells serves as an early event in hepatocarcinogenesis, and they highlight the important roles of Bmi1 and the Wnt/beta-catenin pathway in regulating the self- Renewal of normal or cancer stem cells in liver.
Journal ArticleDOI
Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells.
Yunzhong Nie,Yun-Wen Zheng,Yun-Wen Zheng,Yun-Wen Zheng,Kei Miyakawa,Soichiro Murata,Ran-Ran Zhang,Keisuke Sekine,Yasuharu Ueno,Takanori Takebe,Takaji Wakita,Akihide Ryo,Hideki Taniguchi +12 more
TL;DR: It is demonstrated that HBV infection in hiPSC-LOs could recapitulate virus life cycle and virus induced hepatic dysfunction, suggesting that hiPSCs may provide a promising individualized infection model for the development of individualized treatment for hepatitis.