Randa Hilal-Dandan

TL;DR: The increased expression of hsp27 and alphaB-crystallin through an adenovirus vector system protects against ischemic injury in adult cardiomyocytes and in contrast, the overexpression ofalphaB- Crystallin protects againstIschemic damage in neonatal cardiomeocytes.

TL;DR: It is suggested, for the first time, that increased SERCA2 expression is feasible in vivo and results in enhanced calcium transients, myocardial contractility, and relaxation that may have further therapeutic implications.

TL;DR: The findings suggest that epsilon-PKC is responsible for the phenylephrine-induced phosphorylation of MARCKS, an endogenous PKC-specific substrate.

TL;DR: The data presented here demonstrate that, in a physiologically relevant setting, G-protein is present in large stoichiometric excess relative to both receptor and effector, and shows that adenylate cyclase is the component distal to receptor that limits agonist-mediated increases in cyclic AMP production.

TL;DR: The data indicate that the effects of endothelin on adult cardiac myocytes involve multiple signaling pathways, including enhanced activity of the inositol phosphate pathway and a decrease in cyclic AMP-mediated responses, neither of which seems likely to account for the positive contractile effects ofendothelin.