H
Howard A. Rockman
Researcher at Duke University
Publications - 244
Citations - 23801
Howard A. Rockman is an academic researcher from Duke University. The author has contributed to research in topics: Receptor & Heart failure. The author has an hindex of 81, co-authored 238 publications receiving 22395 citations. Previous affiliations of Howard A. Rockman include Sharp Memorial Hospital & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Seven-transmembrane-spanning receptors and heart function
TL;DR: Understanding precisely how the heart can recognize and respond to many different extracellular signalling molecules, such as neurotransmitters, hormones and growth factors, will aid the identification of new therapeutic targets through which cardiovascular diseases can be combated.
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Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy
Howard A. Rockman,Robert S. Ross,Adrienne N. Harris,Kirk U. Knowlton,Mark E. Steinhelper,Loren J. Field,John Ross,Kenneth R. Chien +7 more
TL;DR: Evidence is provided that atrial-specific and inducible expression of the atrial natriuretic factor gene can be segregated, suggesting that a distinct set of regulatory cis sequences may mediate the up-regulation of the ANF gene during in vivo pressure overload hypertrophy.
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Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor
Carmelo A. Milano,Lee F. Allen,Howard A. Rockman,Paul C. Dolber,T. R. McMinn,Kenneth R. Chien,T. D. Johnson,Richard A. Bond,Robert J. Lefkowitz +8 more
TL;DR: Transgenic mice were created with cardiac-specific overexpression of the beta 2-adrenergic receptor that resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo, suggesting a potential gene therapy approach to this disease state.
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Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.
Walter J. Koch,Howard A. Rockman,Philippe Samama,RaeAnn Hamilton,Richard A. Bond,Carmelo A. Milano,Robert J. Lefkowitz +6 more
TL;DR: Transgenic mice created with cardiac-specific overexpression of the beta-adrenergic receptor kinase-1 (beta ARK1) or a beta ARK inhibitor displayed enhanced cardiac contractility in vivo with or without isoproterenol, demonstrating the important role of Beta ARK in modulating in vivo myocardial function.
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Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
Paula M. Oliver,Jennifer E. Fox,Ron Kim,Howard A. Rockman,Hyung Suk Kim,Robert L. Reddick,Kailash N. Pandey,Sharon L. Milgram,Oliver Smithies,Nobuyo Maeda +9 more
TL;DR: It is reported that mice lacking a functional Npr1 gene coding for NPRA have elevated blood pressures and hearts exhibiting marked hypertrophy with interstitial fibrosis resembling that seen in human hypertensive heart disease.