R
Randall J. Ruch
Researcher at University of Toledo Medical Center
Publications - 67
Citations - 5615
Randall J. Ruch is an academic researcher from University of Toledo Medical Center. The author has contributed to research in topics: Connexin & Cell culture. The author has an hindex of 37, co-authored 67 publications receiving 5368 citations.
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Journal ArticleDOI
Reversal of ras-induced inhibition of gap-junctional intercellular communication, transformation, and tumorigenesis by lovastatin.
TL;DR: It is suggested that lovastatin reversed the transformed phenotype of WB‐ras cells by inhibiting p21 ras plasma membrane association and the concomitant enhancement of GJIC in lovastsatin‐treated cells suggests a role for reduced GJ IC in the expression of the transformation phenotype.
Journal Article
Kinetics of Phenobarbital Inhibition of Intercellular Communication in Mouse Hepatocytes
Randall J. Ruch,James E. Klaunig +1 more
TL;DR: Phenobarbital inhibited mouse hepatocyte dye coupling rapidly and reversibly, and the cells became refractory to the inhibitory effect after prolonged treatment.
Journal ArticleDOI
Growth inhibition of rat liver epithelial tumor cells by monoterpenes does not involve Ras plasma membrane association.
Randall J. Ruch,Kristi Sigler +1 more
TL;DR: Monoterpene-induced growth inhibition of rat liver epithelial cells was dissimilar to lovastatin and did not appear to involve altered Ras plasma membrane association.
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Strain and species effects on the inhibition of hepatocyte intercellular communication by liver tumor promoters.
James E. Klaunig,Randall J. Ruch +1 more
TL;DR: Findings showed a good correlation with the in vivo liver tumor promoting/hepatocarcinogenic actions of PB, DDT and dieldrin in the 4 mouse strains and the F344 rat strain.
Journal ArticleDOI
Comparative effects of phenobarbital, DDT, and lindane on mouse hepatocyte gap junctional intercellular communication.
TL;DR: The kinetics of inhibition of mouse hepatocyte gap junctional intercellular communication by three well-established hepatic tumor promoters are compared and phenobarbital was prevented by addition of the cytochrome P450 enzyme inhibitor SKF-525A and coincubation of the three promoters with the cAMP analog 8-bromo-cAMP prevented the promoter-induced inhibition of inter cellular communication.