R
Randall J. Ruch
Researcher at University of Toledo Medical Center
Publications - 67
Citations - 5615
Randall J. Ruch is an academic researcher from University of Toledo Medical Center. The author has contributed to research in topics: Connexin & Cell culture. The author has an hindex of 37, co-authored 67 publications receiving 5368 citations.
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Journal ArticleDOI
Proteomic analysis of a neoplastic mouse lung epithelial cell line whose tumorigenicity has been abrogated by transfection with the gap junction structural gene for connexin 43, Gja1
TL;DR: Protein expression was analyzed in four related mouse lung epithelial cell lines that vary in their GJIC status and neoplastic potential to provide insights into the molecular pathogenesis of lung cancer.
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Carcinogenicity of chlorinated methane and ethane compounds administered in drinking water to mice.
TL;DR: CHCl3, however, inhibited liver and lung tumorigenesis in the DENA-initiated mice and PB promoted liver tumor formation (but not lung tumors), while 1,1-DCE and 1,2-D CE did not affect the incidence or number of liver or lung tumors in theDENA- initiated animals.
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Down-regulation by Butylated Hydroxytoluene of the Number and Function of Gap Junctions in Epithelial Cell Lines Derived From Mouse Lung and Rat Liver
TL;DR: The data suggest that BHT and TPA inhibit lung and liver epithelial cell GJIC through distinct mechanisms.
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Selective resistance to cytotoxic agents in hepatocytes isolated from partially hepatectomized and neoplastic mouse liver.
TL;DR: Neoplastic hepatocytes were less sensitive to lindane and methotrexate, did not differ in cytotoxic response to diethylnitrosamine and adriamycin and were more sensitive to cycloheximide compared to normal mouse hepatocytes.
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Effects of trichloroethylene and its metabolites on rodent hepatocyte intercellular communication.
TL;DR: The inhibiting effect of TCA only on mouse hepatocytes suggests that other intrinsic factors in the male mouse make this species more susceptible to the effects of TCE and TCA on gap junction mediated intercellular communication.